Abstract:

Objective To investigate the changes of fibrinolytic activity during normal pregnancy for hypercoagulation in Chinese Han population. Methods A total of 100 healthy pregnant women（healthy pregnant group） and 100 healthy unpregnant women（unpregnant control group） were enrolled in the longitudinal study. Fibrinogen（Fg）,fibrin degradation product（FDP）,Fg/FDF ratio,tissue-type plasminogen activator（t-PA）,plasminogen activator inhibitor -1（PAI-1） and t-PA/PAI-1 ratio were evaluated. The correlations of Fg and FDP with t-PA/PAI-1 were analyzed. Results Fg,FDP and Fg/FDP ratio increased with the period of pregnancy（P<0.01）. Compared with unpregnant control group,t-PA,PAI-1 and t-PA/PAI-1 ratio increased in healthy pregnant group（P<0.05）. t-PA/PAI-1 ratio and Fg were positively related during early pregnancy [correlation coefficient （r）=0.81,P<0.05],and t-PA/ PAI-1 ratio was the lowest during middle pregnancy（the degradation rate of Fg was the lowest）. Fg increased significantly during late pregnancy and reached the highest level. The correlation between t-PA/PAI-1 ratio and FDP was positive during early and late pregnancy（r=0.75 and 0.79,P<0.05）. Conclusions In Chinese Han population,their bodies do not trigger coagulation during normal pregnancy. The bodies controls directly elevated Fg by increasing primary fibrinolytic activity,and coagulation / fibrinolysis system maintains balance on high level .

Key words: Fibrinolysis system, Pregnancy, Fibrinogen, Tissue-type plasminogen activator, Plasminogen activator inhibitor-1