The roles of serum ox-LDL/β2-GPI complex in patients with type 2 diabetes mellitus complicated with coronary heart disease

Abstract

Abstract: Objective　To investigate the roles of serum oxidized low density lipoprotein（ox-LDL）/beta2-glycoprotein Ⅰ（β2-GPI） complex in type 2 diabetes mellitus（T2DM）patients complicated with coronary heart disease（CHD）and its clinical significance. Methods　Serum samples were collected from 68 T2DM patients complicated with CHD，69 patients with T2DM，65 patients with CHD and 60 healthy controls.Serum ox-LDL/β2-GPI complex were measured by enzyme-linked immunosorbent assay（ELISA），and the fasting blood glucose（FBG），total cholesterol（TC），triglyceride（TG），high-density lipoprotein holesterol（HDL-C），low-density lipoprotein cholesterol（LDL-C），glycosylated hemoglobin（HbA1C），fasting serum insulin（FINS），body mass index（BMI）and waist to hip ratio（WHR）were determined and analyzed. Results　The T2DM patients complicated with CHD had significantly higher levels of ox-LDL/β2-GPI complex than T2DM group，CHD group and control group（P<0.05）.The ox-LDL/β2-GPI complex level was positively correlated with TG and homeostasis model assessment insulin resistance（HOMA-IR） index in the T2DM patients complicated with CHD（r=0.219 and 0.228，P<0.01）.TG and ox-LDL/β2-GPI complex were the risk factors of T2DM.The ox-LDL/β2-GPI complex and HbA1Cwere the risk factors of T2DM complicated with CHD. Conclusions　Serum ox-LDL/β2-GPI complex may play an important role in the development of T2DM complicated with CHD.

Key words: Low density lipoprotein, Beta2-glycoprotein Ⅰ, Type 2 diabetes mellitus, Coronary heart disease

WANG Liangping. The roles of serum ox-LDL/β2-GPI complex in patients with type 2 diabetes mellitus complicated with coronary heart disease[J]. , 2012, 27(11): 944-947.

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