Abstract:

Objective To study the distribution,drug resistance and homology of food-borne Salmonella in Hanzhong. Methods From January 2018 to December 2018,the isolates of Salmonella were isolated from feces of patients with diarrhea caused by food-borne diseases diagnosed in 3 sentinel hospitals of Hanzhong. The sex,age,serotype and drug resistance of Salmonella were analyzed. Pulsed field gel electrophoresis（PFGE） was used for homology analysis. Results Babies,infants and children accounted for 77.3% of the total population,elders >65years old accounted for 18.9% of the total population,and adults <65 years old accounted for 3.8%. A total of53 isolates were isolated,including 7 serotypes. Salmonella typhimurium（26 isolates）,Salmonella enteritidis（13 isolates） and Salmonella stanley（6 isolates） were the top 3 Salmonella serotypes. The drug resistance rates of Salmonella to carbapenems and fluoroquinolones were <10%. The drug resistance rates of Salmonella to aminoglycosides and cephalosporins were 10%-30%. The drug resistance rates of Salmonella to piperacillin,tetracycline and ampicillin were 97.74%,65.81% and 55.03%,respectively. However,the drug resistance rate of Salmonella enteritidis to tetracycline was only 7.70%. PFGE was used to classify and cluster Salmonella enteritidis and Salmonella typhimurium. There were 3 groups of Salmonella typhimurium with 100% similarity in PFGE fingerprint pattern,and 2 isolates in each group. There were 3 groups of Salmonella enteritidis,of which the most had 7 isolates,and the rest had 2 isolates. Conclusions Food-borne Salmonella infection is common in infants and children in Hanzhong,especially for Salmonella typhimurium. Food-borne Salmonella has a high drug resistance rate to piperacillin,tetracycline and ampicillin. Salmonella enteritidis infection has certain homology.

Key words: Food-borne disease, Salmonella, Drug resistance, Homology