Abstract:

Objective To investigate the distribution and drug resistance of bacteria in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）,and to provide a reference for clinical rational use of drugs. Methods The positive results of sputum culturing and the results of antimicrobial susceptibility test of 107 patients with AECOPD from Beijing Shijitan Hospital of the Capital Medical University were analyzed retrospectively. Results A total of 139 isolates were isolated,58.3% of them were Gram-negative bacilli,25.2% of them were Gram-positive cocci,and 16.5% of them were fungi. Among the Gram-negative bacilli,the main pathogens included Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa. Staphylococcus aureus and Streptococcus pneumoniae were the most common pathogens in Gram-positive cocci. Candida albicans was the most common pathogen in fungi. Klebsiella pneumoniae and Acinetobacter baumannii had the highest drug resistance to cephalosporin antibiotics,but were sensitive to β-lactamase inhibitor compounds. Acinetobacter baumannii was only susceptible to carbapenem and cefoperazone-sulbactam. The antibiotic resistance of Gram-positive cocci was serious,but vancomycin,linezolid and tigecycline were still effective. Conclusions Gram-negative bacilli are predominant pathogens in AECOPD patients from Beijing Shijitan Hospital of the Capital Medical University. The surveillance of bacterial resistance has significance to the clinical use of drugs.

Key words: Chronic obstructive pulmonary disease, Pathogen, Drug resistance