Abstract:

Objective To establish the reference intervals of glycated albumin（GA） in different age groups in Huaihai,which is evaluated by laboratory diagnosis. Methods A total of 1 784 healthy subjects in the Central Hospital of Xuzhou City from January 2017 to January 2018 were enrolled. All the subjects were classified according to different ages. There were 429 children（0-6 years old）,199 juniors（7-17 years old）,203 young people（18-40 years old）,618 middle-aged people（41-65 years old） and 315 elder people（≥66 years old）. The GA levels were determined by enzymatic method. The 95% confidence intervals of reference intervals were calculated. Totally,221 healthy subjects' samples were collected in the Central Hospital of Xuzhou City from May 2018 to June 2018. The results of GA were collected,and the value of R was calculated. The reference interval was verified. There were 1 367 samples which were collected from whom came to the Central Hospital of Xuzhou City from June 1th 2018 to June 5th 2018,which were contained 149 diabetes mellitus patients and 1 218 non-diabetes mellitus patients. The reference interval was evaluated by laboratory diagnosis. Results The reference interval of child group was 6.28%-13.54%,that of junior group was 7.25%-14.93%,that of young group was 8.32%-14.66%,that of middle-aged group was 9.52%-15.64%,and that of elder group was 10.09%-16.29%. The specificity of the reference intervals of GA was 95.00%,the sensitivity was 98.65%,the misdiagnosis rate was 6.89%,and the missed diagnosis rate was 1.34%. Conclusions The reference interval of GA in Huaihai is 7.61%-15.37%. The level of GA increases with ages. It is recommended to set GA reference interval according to different ages. GA has a diagnostic value for diabetes mellitus.

Key words: Glycated albumin, Reference interval, Diabetes mellitus