Abstract:

Objective To review the common pathogens and drug susceptibility of lower respiratory tract infection（LRI） of children,and to provide a reference for the rational use of drugs in clinic. Methods A total of 6 205 patients with LRI were enrolled,the isolated strains through sputum culturing were identified and determined by VITEK 2 Compact automatic microbiology analyzer,and the drug susceptibility was performed. Results From 2014 to 2016,14 species of pathogens （2 147 isolates）were isolated from sputum samples,and the positive rate was 34.6%. The main species were Streptococcus pneumoniae （39.17%,840 isolates）,Haemophilus influenzae （23.43%,503 isolates）,Moraxella catarrhalis（20.63%,443 isolates） and Staphylococcus aureus （7.59%,163 isolates）. Streptococcus pneumoniae had a decreased trend,while Moraxella catarrhalis had an increased trend. The drug resistance rates of penicillin,sulfamethoxazole and other antibiotics were increasing. Conclusions The pathogenic distribution of children with LRI in central and southern Sichuan has its own characteristics. Clinicians should adjust drugs according to the drug resistance changes of pathogens and reduce the risk of drug resistance caused by the improper use of drugs.

Key words: Lower respiratory tract infection, Pathogen, Drug susceptibility, Children