Correlation of blood lipid levels with ankylosing spondylitis

doi:10.3969/j.issn.1673-8640.2017.05.005

Abstract

Abstract:

Objective To study the correlation of blood lipid levels with ankylosing spondylitis （AS）. Methodse A total of 314 AS patients and 138 healthy subjects （healthy control group） were enrolled. Total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HDL-C） and C-reactive protein（CRP） were determined. The correlation of blood lipid levels with AS was evaluated. Results Compared with healthy control group,AS group had increased level of TG and LDL-C/HDL-C ratio （P<0.01） and decreased levels of TC,HDL-C and LDL-C （P<0.01）. TC,TG,HDL-C and LDL-C in AS group were negatively correlated with CRP （r=-0.298,-0.198,-0.256 and -0.259,P=0.001,<0.001,<0.001 and <0.001）. According to CRP levels,AS group was sub-classified into low-level CRP group （CRP≤10 mg/L）,middle-level CRP group （CRP>10-<50 mg/L） and high-level CRP group （CRP≥50 mg/L）. Compared with high-level CRP group,TC,TG,HDL-C and LDL-C were lower than those in low-level CRP group （P<0.01）. There was no statistical significance for LDL-C/HDL-C ratio among the groups （P>0.05）. Conclusions AS patients have blood lipid metabolic disorder. Their blood lipid levels may be correlated with inflammation status.

Key words: Blood lipid, Ankylosing spondylitis, Cardiovascular diseases

CLC Number:

R446.1

WU Zhiqiang, YANG Bin, FENG Weihua, CHEN Jie, HUANG Hengjian. Correlation of blood lipid levels with ankylosing spondylitis[J]. Laboratory Medicine, 2017, 32(5): 370-373.

Figures/Tables 4

References 14

[1]	VAN HALM V P,VAN DENDEREN J C,PETERS M J,et al. Increased disease activity is associated with a deteriorated lipid profile in patients with ankylosing spondylitis[J]. Ann Rheum Dis,2006,65(11):1473-1477.
[2]	HAROON N N,PATERSON J M,LI P,et al.Patients with ankylosing spondylitis have increased cardiovascular and cerebrovascular mortality:a population-based study[J]. Ann Intern Med,2015,163(6):409-416.
[3]	PETERS M J,SYMMONS D P,MCCAREY D,et al.EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis[J]. Ann Rheum Dis,2010,69(2):325-331.
[4]	杜旭娜,李晏,张胜利,等. 强直性脊柱炎病情活动度评分对强直性脊柱炎患者病情活动性判断的价值[J]. 中华内科杂志,2012,51(3): 206-209.
[5]	MATHIES H.Diagnostic criteria in ankylosing spondylitis[J]. Dtsch Med Wochenschr,1984,109(10):382-385.
[6]	徐瑞霞,李建军. 氧化型低密度脂蛋白胆固醇与动脉粥样硬化[J]. 中国循环杂志,2012,27(3):223-223.
[7]	TSAI W C,OU T T,YEN J H,et al.Long-term frequent use of non-steroidal anti-inflammatory drugs might protect patients with ankylosing spondylitis from cardiovascular diseases: a nationwide case-control study[J]. PLoS One, 2015,10(5):e0126347.
[8]	NIEDERMANN K,SIDELNIKOV E,MUGGLI C,et al.Effect of cardiovascular training on fitness and perceived disease activity in people with ankylosing spondylitis[J]. Arthritis Care Res(Hoboken),2013,65(11):1844-1852.
[9]	SERDAROGLU BEYAZAL M,ERDOGAN T,TüRKYILMAZ A K,et al. Relationship of serum osteoprotegerin with arterial stiffness,preclinical atherosclerosis,and disease activity in patients with ankylosing spondylitis[J]. Clin Rheumatol, 2016, 35(9):2235-2241.
[10]	何袁芳,晋志高. 低脂饮食及体能锻炼对中年人血清总胆固醇的影响[J]. 环境与职业医学,2007,24(2):215-217.
[11]	邹远泉,周跃,钟山,等. LDL-C /HDL-C比值在中青年症状性动脉粥样硬化颅内动脉狭窄患者中的临床价值[J]. 中国临床研究,2015,28(3):308-310.
[12]	BERG I J,VAN DER HEIJDE D,DAGFINRUD H,et al. Disease activity in ankylosing spondylitis and associations to markers of vascular pathology and traditional cardiovascular disease risk factors: a cross-sectional study[J]. J Rheumatol,2015,42(4):645-653.
[13]	MATHIEU S,SOUBRIER M.Cardiovascular risk in ankylosing spondylitis[J]. Presse Med,2015,44(9):907-911.
[14]	VERMA I,SYNGLE A,KRISHAN P.Endothelial progenitor cell biology in ankylosing spondylitis[J]. Int J Rheum Dis,2015,18(3):336-340.

组别	AS家族史（例）	CRP （mg/L）	HLA-B27（+）（例）
AS组	16	1.01~168.00	314
正常对照组	-	<10.00	-

组别	AS家族史（例）	CRP （mg/L）	HLA-B27（+）（例）
AS组	16	1.01~168.00	314
正常对照组	-	<10.00	-

组别	例数	TG（mmol/L）	TC（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	LDL-C/HDL-C比值
AS组	314	1.16±0.84	4.22±0.95	1.33±0.36	2.39±0.74	1.92±0.76
正常对照组	138	1.04±0.34	4.65±0.59	1.59±0.37	2.58±0.55	1.72±0.58
P值		0.024	<0.001	<0.001	0.003	0.002

组别	例数	TG（mmol/L）	TC（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	LDL-C/HDL-C比值
AS组	314	1.16±0.84	4.22±0.95	1.33±0.36	2.39±0.74	1.92±0.76
正常对照组	138	1.04±0.34	4.65±0.59	1.59±0.37	2.58±0.55	1.72±0.58
P值		0.024	<0.001	<0.001	0.003	0.002

项目	TG			TC			HDL-C			LDL-C
项目	B值	R²值	P值	B值	R²值	P值	B值	R²值	P值	B值	R²值	P值
性别	0.011		0.487	-0.197		0.261	0.250		<0.001	-0.266		0.031
年龄	-0.232	0.113	0.001	0.023	0.179	<0.001	0.005	0.216	<0.001	0.015	0.147	<0.001
CRP	-0.005		0.354	-0.010		0.005	-0.003		<0.001	-0.007		0.032