Abstract: Objective　To research the dynamic changes and clinical significance of serum ischemia-modified albumin（IMA） in patients with early traumatic craniocerebral injury.   Methods　A total of 90 patients with traumatic craniocerebral injury were classified into 3 groups according to the Glasgow Coma scale（GCS） scores [score 13-15：mild injury group（29 cases），score 9-12：medium injury group（29 cases） and score 3-8：severe injury group（32 cases）]，and 36 healthy subjects were enrolled as healthy controls. The levels of serum IMA，C reactive protein（CRP） and myeloperoxidase（MPO） were determined in patient group at 3，6，12，24，48 and 72 h after injury and in healthy control group. Results　The levels of serum IMA at 3-72 h after injury in patients with traumatic craniocerebral injury were significantly higher than those in healthy control group（P＜0.01） and increased with the degree of injury，and the levels of serum IMA in mild injury group were lower than those in medium and severe injury groups（P＜0.01）. The levels of serum IMA in early injury had no change with the development of the disease（P＞0.10），and there was a positive correlation with CRP and MPO. Conclusions　The levels of serum IMA are significantly increasing continuously because of oxygen lack and inflammation reaction in patients with early traumatic craniocerebral injury，and are related positively with the severity of disease. IMA has the significance for the severity evaluation，secondary craniocerebral injury and therapy in patients with early traumatic craniocerebral injury.

Key words: Ischemia-modified albumin, Traumatic craniocerebral injury, C reactive protein, Myeloperoxidase