Abstract:

Objective To investigate the significance of homocysteine (Hcy), mean platelet volume (MPV), high-sensitivity C reactive protein (hs-CRP) and fibrinogen (FIB) in the diagnosis of acute cerebral infarction.Methods A total of 130 patients with acute cerebral infarction were enrolled. According to the degree of nerve defect, they were classified into mild group (37 cases), moderate group (62 cases) and severe group( 31 cases), and 70 healthy subjects were enrolled as control group. The correlations of each index between acute cerebral infarction group and control group were analyzed. Results Hcy, MPV, hs-CRP and FIB levels in acute cerebral infarction group were significantly higher than those in control group (P<0.05). Among mild, moderate and severe groups, Hcy, MPV, hs-CRP and FIB had statistical significance (P<0.05). The nerve defect degree was heavier, Hcy, MPV, hs-CRP and FIB levels were higher. Compared with 2 indices of Hcy, MPV, hs-CRP and FIB for each other, there was a significantly positive correlation (P<0.05). Conclusions Among patients with acute cerebral infarction, their Hcy, MPV, hs-CRP and FIB significantly increase, and are closely related the severity of disease. The determinations of Hcy, MPV, hs-CRP and FIB have important significance for the progress and prognosis.

Key words: Homocysteine, Mean platelet volume, High-sensitivity C reactive protein, Fibrinogen