抗α-胞衬蛋白对干燥综合征的诊断价值：一项meta分析

检验医学 ›› 2012, Vol. 27 ›› Issue (12): 1074-1079.

抗α-胞衬蛋白对干燥综合征的诊断价值：一项meta分析

秦琴¹,孙懿¹,谷明莉¹,胡志德¹,陈孙孝¹,邓安梅²

1.第二军医大学附属长海医院实验诊断科，上海 200433；2.济南军区总医院实验诊断科，山东济南 250031；3.第二军医大学附属长征医院皮肤科，上海 200003

收稿日期:2012-09-28 修回日期:2012-08-18 出版日期:2012-12-30 发布日期:2012-12-04
通讯作者: 邓安梅，联系电话：021-81874093。
作者简介:秦琴，女，1978年生，硕士，主治医师，主要从事临床免疫学研究。
基金资助:
国家自然科学基金资助项目（30972730）；上海市科委基金资助项目（09JC1405400，11JC1410902）

A meta analysis on the diagnosis significance of anti-alpha-fodrin antibodies for Sj gren′s syndrome

1. Department of Laboratory Diagnosis，Changhai Hospital，Second Military Medical University，Shanghai 200433，China；2. Department of Laboratory Diagnosis，General Hospital of Jinan Military Command Region，Shandong Jinan 250031，China；3. Department of Dermatology，Changzheng Hospital，Second Military Medical University，Shanghai 200003，China

Received:2012-09-28 Revised:2012-08-18 Online:2012-12-30 Published:2012-12-04

摘要/Abstract

摘要： 目的　探讨抗α-胞衬蛋白抗体对干燥综合征（SS）的诊断价值。方法　对已经发表的采用酶联免疫吸附试验（ELISA）检测抗α-胞衬蛋白抗体诊断SS（以2002年国际标准为诊断依据）的文献进行了分析，并且采用随机效应模型分析了ELISA检测抗α-胞衬蛋白抗体对SS的总体诊断敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）和诊断优势比（DOR）。以汇总受试者工作特征（sROC）曲线分析抗α-胞衬蛋白抗体的总体诊断性能。结果　最终有7项研究进入了本次meta分析，ELISA检测抗α-胞衬蛋白抗体IgA、IgG的总体诊断敏感性[95％可信区间（CI）]分别为0.30（0.25～0.34）和0.32（0.28～0.36），总体特异性分别为0.90（0.87～0.93）和0.83（0.80～0.86）。已有的研究质量并不高，且之间存在较大的异质性。结论　抗α-胞衬蛋白抗体对SS具有较高的诊断特异性，但其诊断敏感性并不理想。对抗α-胞衬蛋白抗体的结果解释应建立在患者临床特征之上。

关键词: 抗α-胞衬蛋白抗体, 干燥综合征, meta分析

Abstract: Objective　To investigate the diagnosis significance of anti-alpha-fodrin antibodies for Sjgren′s syndrome（SS）. Methods　After a systematic review of literatures，the sensitivity，specificity，positive and negative likelihood ratios（PLR/NLR） and diagnosis advantage ratio（DOR） of anti-alpha-fodrin antibodies by enzyme-linked immunosorbent assay（ELISA） in the diagnosis of SS defined by international 2002 criteria were pooled by random-effect models. Summary receiver operating characteristic（sROC） curves were used to summarize the overall determination performance. Results　Seven studies met the criteria. The summary evaluations for anti-alpha-fodrin antibody IgA and IgG in the diagnosis of SS were as follows：sensitivities 0.30 [95% confidence interval（CI） 0.25-0.34] and 0.32（95% CI 0.28-0.36）；specificities 0.90（95%CI 0.87-0.93） and 0.83（95% CI 0.80-0.86），respectively. The designed studies were with low quality，and the significant heterogeneity was observed. Conclusions　Anti-alpha-fodrin antibodies have poor sensitivity and high specificity for the diagnosis of SS. The explanation for anti-alpha-fodrin antibody determination result should be based on clinicalfeatures.

Key words: Anti-alpha-fodrin antibody, Sj gren′s syndrome, Meta analysis

秦琴1，孙懿1，谷明莉1，胡志德2，陈孙孝3，邓安梅1. 抗α-胞衬蛋白对干燥综合征的诊断价值：一项meta分析[J]. 检验医学, 2012, 27(12): 1074-1079.

QIN Qin 1，SUN Yi 1，GU Mingli 1，HU Zhide 2，CHEN Sunxiao 3，DENG Anmei 1. A meta analysis on the diagnosis significance of anti-alpha-fodrin antibodies for Sj gren′s syndrome[J]. , 2012, 27(12): 1074-1079.

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