关键词: 人乳头瘤病毒, 宫颈癌, 宫颈上皮内瘤变, 下生殖道, 病原菌

Abstract:

Objective To investigate the relationship between human papillomavirus （HPV） infection with Chlamydia trachomatis（CT）and Ureaplasma urealyticum（UU）lower genital tract pathogen infections and cervical lesion. Methods From August 2019 to January 2021，935 female patients，aged 17-73 years old，were enrolled from Qingyuan Hospital of Guangzhou Medical University. There were 241 cases of menelipsis（25.78%），453 cases of cervicitis （48.45%），92 cases of cervical cancer （9.84%），184 cases of cervical intraepithelial neoplasia （CIN）Ⅰ（19.68%），68 cases of CIN Ⅱ（7.27%） and 138 cases of CIN Ⅲ（14.76%）. CT and UU of vaginal or cervical secretions were determined by fluorescence quantitative polymerase chain reaction（PCR）. HPV genotyping and CT and UU determinations were performed in 235 patients. Pearson correlation analysis was used to evaluate the correlation between HPV combined with lower genital tract pathogen infection and cervical lesion. Results CT and UU infections were correlated with HPV infection，and the odds ratio（OR）was 1.16（P<0.001）. The infection rates of high-risk HPV and low-risk HPV had statistical significance between CT and UU infected and uninfected subjects（P<0.05）. The cervical lesion caused by high-risk HPV combined CT and UU infections had statistical significance from those caused by low-risk HPV combined CT and UU infections （P<0.05）. Conclusions High-risk HPV combined with CT and UU infections may be related to the occurrence and development of cervical lesion.

Key words: Human papillomavirus, Cervical cancer, Cervical epithelioma, Lower genital tract, Pathogen