人附睾蛋白4和细胞角蛋白19片段联合检测在非小细胞肺癌辅助诊断中的意义

检验医学 ›› 2014, Vol. 29 ›› Issue (12): 1215-1217.

人附睾蛋白4和细胞角蛋白19片段联合检测在非小细胞肺癌辅助诊断中的意义

张平¹, 周洪兴¹, 白阳¹, 胡玉静¹, 孙颖昕¹, 张红²

1.南京医科大学附属常州第二人民医院检验科，江苏常州 213003；2.南京中医药大学附属常州中医医院检验科，江苏常州 213003

收稿日期:2014-07-24 出版日期:2014-12-30 发布日期:2015-01-14
通讯作者: 张红,联系电话：0519-89896750。
作者简介:张平,男,1972年生,硕士,副主任技师,主要从事临床检验诊断学研究。

Significance on the combined detection of human epididymis protein 4 and CYFRA21-1 in the diagnosis of non-small cell lung cancer

ZHANG Ping¹, ZHOU Hongxing¹, BAI Yang¹, HU Yujing¹, SUN Yingxin¹, ZHANG Hong²

1.Department of Clinical Laboratory, Changzhou Second People's Hospital, Nanjing Medical University, Jiangsu Changzhou 213003, China；2. Department of Clinical Laboratory, Changzhou Traditional Chinese Medicine Hospital, Nanjing Traditional Chinese Medicine University, Jiangsu Changzhou 213003, China

Received:2014-07-24 Online:2014-12-30 Published:2015-01-14

摘要/Abstract

摘要：

目的　探讨人附睾蛋白4（HE4）和细胞角蛋白19片段（CYFRA21-1）联合检测在非小细胞肺癌（NSCLC）辅助诊断中的意义。方法　采用电化学发光法分别检测50例NSCLC患者、40例肺炎患者和50名健康体检者血清HE4、CYFRA21-1水平，通过受试者工作特征（ROC）曲线评价2项指标联合检测对NSCLC辅助诊断的价值。结果　肺癌患者整体CYFRA21-1、HE4水平及Ⅰ~Ⅱ期肺癌患者HE4水平显著高于肺炎患者及健康体检者（P＜0.05）。Ⅲ~Ⅳ期NSCLC患者HE4及CYFRA21-1水平高于Ⅰ~Ⅱ期NSCLC患者（P＜0.05）。经ROC曲线分析，HE4和CYFRA21-1联合检测的敏感性显著高于任一单项检测的敏感性。结论　血清HE4检测比CYFRA21-1对于NSCLC有更高的早期诊断价值。联合检测HE4和CYFRA21-1对诊断NSCLC有较高的敏感性，适用于临床的肺癌普查。

关键词: 人附睾蛋白4, 细胞角蛋白19片段, 非小细胞肺癌

Abstract:

Objective　To investigate the significance on the combined detection of human epididymis protein 4（HE4） and cytokeratin 19 fragment（CYFRA21-1） in the diagnosis of non-small cell lung cancer（NSCLC）. Methods　The levels of serum HE4 and CYFRA21-1 were detected in 50 NSCLC patients， 40 patients with pneumonia and 50 healthy subjects. The diagnosis significance of the combined detection of serum HE4 and CYFRA21-1 for NSCLC was analyzed by receiver operating characteristic（ROC） curve. Results　The levels of serum CYFRA21-1 and HE4 in all the NSCLC patients and the level of HE4 in patients with Ⅰ-Ⅱ stages of NSCLC were significantly higher than those in pneumonia patients and healthy subjects（P＜0.05）. The levels of serum HE4 and CYFRA21-1 in patients with Ⅲ-Ⅳ stages of NSCLC were significantly higher than those in patients with Ⅰ-Ⅱ stages of NSCLC（P＜0.05）. The sensitivity of the combined detection was high than that of any single detection. Conclusions　The detection of serum HE4 has a high significance for the early diagnosis of NSCLC compared with CYFRA21-1 detection. The combined detection of HE4 and CYFRA21-1 for the diagnosis of NSCLC has a high sensitivity， and is suitable for the clinical screening of lung cancer.

Key words: Human epididymis protein 4, Cytokeratin 19 fragment, Non-small cell lung cancer

中图分类号:

R446.62

张平, 周洪兴, 白阳, 胡玉静, 孙颖昕, 张红. 人附睾蛋白4和细胞角蛋白19片段联合检测在非小细胞肺癌辅助诊断中的意义[J]. 检验医学, 2014, 29(12): 1215-1217.

ZHANG Ping, ZHOU Hongxing, BAI Yang, HU Yujing, SUN Yingxin, ZHANG Hong. Significance on the combined detection of human epididymis protein 4 and CYFRA21-1 in the diagnosis of non-small cell lung cancer[J]. , 2014, 29(12): 1215-1217.

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