关于腺病毒是否为近期儿童不明原因肝炎病原的思考

doi:10.3969/j.issn.1673-8640.2022.08.001

检验医学 ›› 2022, Vol. 37 ›› Issue (8): 705-709.DOI: 10.3969/j.issn.1673-8640.2022.08.001

• 专家论坛 • 下一篇

关于腺病毒是否为近期儿童不明原因肝炎病原的思考

卢丽娟, 徐锦()

国家儿童医学中心复旦大学附属儿科医院,上海 201102

收稿日期:2022-06-01 修回日期:2022-07-18 出版日期:2022-08-30 发布日期:2022-09-16
通讯作者: 徐锦
作者简介:徐锦,E-mail： jinxu_125@163.com。
卢丽娟,女,1985年生,硕士,主管技师,主要从事病毒流行病学和感染机制研究。

Thoughts on whether adenovirus is the cause of the hepatitis of unknown etiology among children recently

LU Lijuan, XU Jin()

National Childen's Medical Center,the Children's Hospital of Fudan University,Shanghai 201102,China

Received:2022-06-01 Revised:2022-07-18 Online:2022-08-30 Published:2022-09-16
Contact: XU Jin

摘要/Abstract

摘要：

近期,儿童不明原因肝炎在多个国家和地区呈现集中发生的趋势,引起世界卫生组织（WHO）的关注。依据现有病例的相关报道,已有众多假说被提出。其中,关于腺病毒可能是此轮儿童不明原因肝炎病因的推测广受争议。文章从儿童不明原因肝炎的发生、腺病毒的致病特点和腺病毒肝炎的既往报道出发,就可能引起儿童不明原因肝炎的病原进行分析,并就明确病原需开展的工作提出建议,为中国一旦发生相关病例时能够及时、准确地进行诊断提供参考。

关键词: 腺病毒, 新型冠状病毒, 不明原因肝炎, 儿童

Abstract:

Recently,the hepatitis of unknown etiology among children has shown a concentrated trend in many countries and regions,which has aroused concern from the World Health Organization. Based on the reports of existing cases,numerous hypotheses have been proposed,among which the hypothesis that adenovirus may be the cause of the hepatitis of unknown etiology among children is debated widely. According to the occurrence of the hepatitis of unknown etiology among children,the pathogenic characteristics of adenovirus and literatures on adenovirus hepatitis,this review analyzes the pathogens that may cause the hepatitis of unknown etiology among children and puts forward suggestions on the work to be carried out to clarify the pathogens. All of those details may provide a direction for timely and accurate diagnosis of related cases in China.

Key words: Adenovirus, Severe acute respiratory syndrome coronavirus, Hepatitis of unknown etiology, Children

中图分类号:

R446.1

卢丽娟, 徐锦. 关于腺病毒是否为近期儿童不明原因肝炎病原的思考[J]. 检验医学, 2022, 37(8): 705-709.

LU Lijuan, XU Jin. Thoughts on whether adenovirus is the cause of the hepatitis of unknown etiology among children recently[J]. Laboratory Medicine, 2022, 37(8): 705-709.

参考文献 16

[1]	World Health Organization. Multi-country-acute,severe hepatitis of unknown origin in children[EB/OL]. (2022-04-23)[2022-04-30]. https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON376.
[2]	World Health Organization. Acute hepatitis of unknown aetiology in children-multi-country[EB/OL]. (2022-05-27)[2022-05-27]. https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON389.
[3]	MARSH K, TAYLER R, POLLOCK L, et al. Investigation into cases of hepatitis of unknown aetiology among young children,Scotland,1 January 2022 to 12 April 2022[J]. Euro Surveill, 2022, 27(15):2200318.
[4]	IDO EFRATI. Israel examining 12 cases of kids' hepatitis after WHO warning[N]. Haaretz, 2022-04-21.
[5]	BAKER J M, BUCHFELLNER M, BRITT W, et al. Acute hepatitis and adenovirus infection among children-Alabama,October 2021-February 2022[J]. MMWR Morb Mortal Wkly Rep, 2022, 71(18):638-640. DOI URL
[6]	UK Health Security Agency. Technical briefing 2:investigation into acute hepatitis of unknown aetiology in children in England[EB/OL]. (2022-04-25)[2022-04-30]. https://www.gov.uk/government/publications/acute-hepatitis-technical-briefing.
[7]	SHIEH W J. Human adenovirus infections in pediatric population-an update on clinico-pathologic correlation[J]. Biomed J, 2022, 45(1):38-49. DOI URL
[8]	ECHAVARRÍA M. Adenoviruses in immunocompromised hosts[J]. Clin Microbiol Rev, 2008, 21(4):704-715. DOI URL
[9]	ROY S, CALCEDO R, MEDINA-JASZEK A, et al. Adenoviruses in lymphocytes of the human gastro-intestinal tract[J]. PLoS One, 2011, 6(9):e24859. DOI URL
[10]	RONAN B A, AGRWAL N, CAREY E J, et al. Fulminant hepatitis due to human adenovirus[J]. Infection, 2014, 42(1):105-111. DOI URL
[11]	SCHABERG K B, KAMBHAM N, SIBLEY R K, et al. Adenovirus hepatitis:clinicopathologic analysis of 12 consecutive cases from a single institution[J]. Am J Surg Pathol, 2017, 41(6):810-819. DOI URL
[12]	XING Y H, NI W, WU Q, et al. Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019[J]. J Microbiol Immunol Infect, 2020, 53(3):473-480. DOI URL
[13]	YONKER L M, GILBOA T, OGATA A F, et al. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier[J]. J Clin Invest, 2021, 131(14):e149633.
[14]	ANTALA S, DIAMOND T, KOCIOLEK L K, et al. Severe hepatitis in pediatric coronavirus disease 2019[J]. J Pediatr Gastroenterol Nutr, 2022, 74(5):631-635. DOI URL
[15]	CHENG M H, ZHANG S, PORRITT R A, et al. Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation[J]. Proc Natl Acad Sci U S A, 2020, 117(41):25254-25262. DOI URL
[16]	YAROVINSKY T O, MOHNING M P, BRADFORD M A, et al. Increased sensitivity to staphylococcal enterotoxin B following adenoviral infection[J]. Infect Immun, 2005, 73(6):3375-3384. DOI URL

关于腺病毒是否为近期儿童不明原因肝炎病原的思考

Thoughts on whether adenovirus is the cause of the hepatitis of unknown etiology among children recently

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 16

相关文章 15

编辑推荐

Metrics

[1]	王慧英, 汤昱, 董利利, 王静. 肺炎支原体RNA检测用于肺炎患儿疾病诊断和疗效监测[J]. 检验医学, 2023, 38(9): 865-869.
[2]	赵若楠, 盛哲, 叶志成, 杨丹, 余先智. 上海某儿科医院新型冠状病毒肺炎疫情前后腹泻患儿A组轮状病毒流行特征[J]. 检验医学, 2023, 38(9): 890-892.
[3]	石迎迎, 潘芬, 孙燕, 王春, 蒋婕, 于方圆, 张天栋, 秦惠宏, 张泓. 巢式多重聚合酶链反应快速诊断儿童脑膜炎/脑炎[J]. 检验医学, 2023, 38(8): 766-770.
[4]	符利梅, 杨丹, 徐锦, 朱海燕, 朱芬华. 全血微量元素和血清维生素检测在6种儿童常见皮肤病中的临床意义[J]. 检验医学, 2023, 38(8): 771-775.
[5]	杨雪, 朱俊, 蒋玲丽, 王青, 胡晓波. 上海地区9种新型冠状病毒核酸检测试剂盲样检测结果一致性分析[J]. 检验医学, 2023, 38(8): 776-780.
[6]	杜晶辉, 贺鑫, 刘晶, 刘瑞岩, 鲍志军, 王俊, 赵岩, 雷曜荣, 刘旻, 刘旭. 新型冠状病毒核酸检测7种振荡混匀方法效果评价[J]. 检验医学, 2023, 38(7): 680-685.
[7]	张欣, 马丽娟. 儿童心脏标志物检测的临床意义[J]. 检验医学, 2023, 38(6): 505-509.
[8]	杨琼, 徐芬, 蔺亚晖. 心肌肌钙蛋白检测在儿科心脏受累相关疾病中的临床应用[J]. 检验医学, 2023, 38(6): 510-517.
[9]	李莉, 孙海燕, 李媛睿, 窦敏, 汤文, 蒋黎敏, 沈立松. 先天性心脏病患儿围手术期NT-proBNP、 PCT变化及其临床意义[J]. 检验医学, 2023, 38(6): 524-531.
[10]	肖秀美, 梁超, 刘彩红, 李晓光. 新型冠状病毒中和抗体与特异性抗体检测结果一致性分析[J]. 检验医学, 2023, 38(4): 352-356.
[11]	李育敏, 付晓歌, 龚海娜, 郭东月, 曾子朗, 姚洁仪, 邓巧梅, 李双, 张秀明. 新型冠状病毒核酸检测假阴性和假阳性案例分析[J]. 检验医学, 2023, 38(4): 378-381.
[12]	李卫滨, 李瑞斌, 张胜行. 新型冠状病毒变异株生物学特性及其检测方法[J]. 检验医学, 2023, 38(4): 394-398.
[13]	王雅玲, 黄运丽, 田密, 王顺兰, 肖莉. 急性支气管肺炎患儿EOS%、CCR3、Eotaxin与病情严重程度的关系[J]. 检验医学, 2023, 38(3): 230-234.
[14]	曾艳芬, 吴泉明, 周欢, 张秋琴, 康艳丽, 李瑶, 陈喜军, 黄建刚, 陈发林. 一种新型冠状病毒核酸检测试剂在4个检测体系中的检出限分析[J]. 检验医学, 2023, 38(3): 261-266.
[15]	武晋英, 方玉莲, 王维, 侯梦珠, 王露, 赵煜. 天津地区急性腹泻患儿肠道病毒感染临床特征和流行病学分析[J]. 检验医学, 2023, 38(3): 267-271.