非肿瘤患者血浆鳞状上皮细胞癌抗原升高的研究进展

doi:10.3969/j.issn.1673-8640.2019.06.021

摘要/Abstract

摘要：

鳞状上皮细胞癌抗原（SCC-Ag）是一种肿瘤相关蛋白,在健康人血浆中的浓度非常低,多用于肿瘤的诊断、疗效监测及预后评估。然而,在SCC-Ag的临床应用中发现,检测方法、特定的生理及病理过程等多种因素会导致非肿瘤患者血浆SCC-Ag升高,给临床相关疾病的诊疗造成了一定的困惑。文章综述了近年来有关SCC-Ag的研究进展,分析了SCC-Ag在非肿瘤状态下的升高情况,以便更好地理解SCC-Ag的特性,帮助正确解释和使用SCC-Ag的检测结果。

关键词: 鳞状上皮细胞癌抗原, 非肿瘤疾病, 肾病, 皮肤病, 肝病, 肺病

Abstract:

Squamous cell carcinoma antigen（SCC-Ag） is a kind of tumor-associated protein with very low plasma level in healthy subjects,and plasma SCC-Ag detection plays a role in the diagnosis,treatment monitoring and prognosis judgement of tumor patients. However,in the clinical application process,SCC-Ag in plasma of non-tumor patients could be increased due to a variety of reasons,such as detection methodology,specific physiological and pathological processes,which causes confusion in clinical diagnosis and treatment. In this review,the increasing of SCC-Ag in non-tumor status has been reviewed in order to understand the characteristics of SCC-Ag and SCC-Ag detection results correctly.

Key words: Squamous cell carcinoma antigen, Non-tumor disease, Kidney disease, Skin disease, Hepatopathy, Lung disease

中图分类号:

R446.5

张蓉, 甘洁民, 陈微雅, 赵虎. 非肿瘤患者血浆鳞状上皮细胞癌抗原升高的研究进展[J]. 检验医学, 2019, 34(6): 567-570.

ZHANG Rong, GAN Jiemin, CHEN Weiya, ZHAO Hu. Research progress on the increasing of plasma squamous cell carcinoma antigen in non-tumor patients[J]. Laboratory Medicine, 2019, 34(6): 567-570.

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