乙型肝炎病毒Pre-S/S区基因突变对乙型肝炎病毒表面抗原检测的影响

doi:10.3969/j.issn.1673-8640.2018.10.018

检验医学 ›› 2018, Vol. 33 ›› Issue (10): 949-953.DOI: 10.3969/j.issn.1673-8640.2018.10.018

乙型肝炎病毒Pre-S/S区基因突变对乙型肝炎病毒表面抗原检测的影响

何成山综述¹, 马晨芸², 陆志成审校²

1.蚌埠医学院,安徽蚌埠 233000
2.上海中医药大学附属第七人民医院医学检验科,上海 200137

收稿日期:2017-12-12 出版日期:2018-10-30 发布日期:2018-10-23
作者简介:null
作者简介：何成山,男,1993年生,学士,主要从事临床免疫学检验工作。
基金资助:
上海市卫生和计划生育委员会科研课题面上项目（201440353）;上海市浦东新区卫生和计划生育委员会重要薄弱学科建设项目（PWZbr2017-01）

Influence of hepatitis B virus Pre-S/S region gene mutation on hepatitis B surface antigen determination

HE Chengshan¹, MA Chenyun², LU Zhicheng²

1. Bengbu Medical University,Bengbu 233000,Anhui,China
2. Department of Clinical Laboratory,the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China

Received:2017-12-12 Online:2018-10-30 Published:2018-10-23

摘要/Abstract

摘要：

乙型肝炎表面抗原（HBsAg）是诊断乙型肝炎病毒（HBV）感染最常用的标志物。近年来,HBV基因组Pre-S/S区突变和氨基酸置换引起HBsAg漏检现象受到广泛关注。探讨中国地区流行性HBV突变株造成HBsAg漏检的原因对于乙型病毒性肝炎的预防、治疗监测及输血安全至关重要。文章就该方面的最新研究作一综述。

关键词: 乙型肝炎表面抗原, 乙型肝炎病毒, 基因突变

Abstract:

Hepatitis B surface antigen（HBsAg） is the most commonly used marker for the diagnosis of hepatitis B virus（HBV） infection. In recent years,the mutations in Pre-S/S region of HBV genome and amino acid replacement have received widespread attentions. This review summarizes the reasons for the missed determination of HBsAg for Chinese epidemic HBV-mutant strains,which is crucial for the prevention and surveillance of HBV infection and the safety of blood transfusion.

Key words: Hepatitis B surface antigen, Hepatitis B virus, Gene mutation

中图分类号:

R446.1

何成山综述, 马晨芸, 陆志成审校. 乙型肝炎病毒Pre-S/S区基因突变对乙型肝炎病毒表面抗原检测的影响[J]. 检验医学, 2018, 33(10): 949-953.

HE Chengshan, MA Chenyun, LU Zhicheng. Influence of hepatitis B virus Pre-S/S region gene mutation on hepatitis B surface antigen determination[J]. Laboratory Medicine, 2018, 33(10): 949-953.

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乙型肝炎病毒Pre-S/S区基因突变对乙型肝炎病毒表面抗原检测的影响

Influence of hepatitis B virus Pre-S/S region gene mutation on hepatitis B surface antigen determination

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