血清类黏蛋白的功能和临床意义

doi:10.3969/j.issn.1673-8640.2018.10.017

检验医学 ›› 2018, Vol. 33 ›› Issue (10): 943-948.DOI: 10.3969/j.issn.1673-8640.2018.10.017

血清类黏蛋白的功能和临床意义

王志学¹, 侯晓丹², 金新源¹, 宋明明¹, 刘霞³, 杨义力²

1. 苏州市立医院北区烧伤整形科,江苏苏州 215008
2. 中国医学科学院系统医学研究中心苏州系统医学研究所,江苏苏州 215123
3. 第二军医大学药学院药理学教研室,上海 200433

收稿日期:2017-10-18 出版日期:2018-10-30 发布日期:2018-10-23
作者简介:null
作者简介：王志学,男,1958年生,学士,主任医师,主要从事重度烧伤救治、深度创面修复研究。
基金资助:
中国医学科学院创新工程重大项目（2016-I2M-1-005）;苏州市临床医学中心建设项目（Szzxj201506）

Function and clinical role of serum orosomucoid

WANG Zhixue¹, HOU Xiaodan², JIN Xinyuan¹, SONG Mingming¹, LIU Xia³, YANG Yili²

1. Department of Burn and Plastic Surgery,North Campus, Suzhou Municipal Hospital,Suzhou 215008,Jiangsu,China
2. Center of System Medicine,Chinese Academy of Medical Sciences,Suzhou Institute of System Medicine,Suzhou 215123,Jiangsu,China
3. Department of Pharmacology,College of Pharmacy,the Second Military Medical University,Shanghai 200433,China

Received:2017-10-18 Online:2018-10-30 Published:2018-10-23

摘要/Abstract

摘要：

类黏蛋白（ORM）属于急性时相反应蛋白,机体许多组织和细胞均能合成,但主要的合成器官是肝脏。ORM能够调节参与天然免疫和获得性免疫的多种细胞,平衡机体的能量代谢,并具有抗疲劳作用。许多组织损伤均可诱导细胞及血中的ORM升高。在感染和创伤的过程中,血中ORM水平在炎症的多个阶段均持续升高。因此,监测血中ORM水平能够与C反应蛋白（CRP）互补,反映炎症性疾病的持续、进展和消退情况,从而为精准治疗提供新的线索。文章从ORM的结构特征、生物功能以及检测ORM的临床意义等方面对ORM进行综合性的阐述。

关键词: 类黏蛋白, C反应蛋白, 天然免疫, 获得性免疫

Abstract:

Orosomucoid（ORM） is an acute phase reactive protein synthesized by many tissues and cells,but the liver is the main organ that synthesizes ORM. ORM can adjust various cells participating in innate and acquired immunity,balance energy metabolism,and fight fatigue. The levels of ORM in cells and blood have been shown to increase dramatically resulting from various tissue injuries. In the process of infection or trauma, blood ORM levels are continuously elevated in the multiple phases of inflammation. Therefore,monitoring the level of ORM in blood can be complemented with the current clinical index of emergency response C-reactive protein（CRP）. ORM can reflect the persistent,progress and fade status of inflammatory diseases and provide new clues to precise treatment. This review makes a comprehensive exposition of ORM from the aspects of structure,biological function and clinical significance of determining ORM.

Key words: Orosomucoid, C-reactive protein, Innate immunity, Acquired immunity

中图分类号:

R446.1

王志学, 侯晓丹, 金新源, 宋明明, 刘霞, 杨义力. 血清类黏蛋白的功能和临床意义[J]. 检验医学, 2018, 33(10): 943-948.

WANG Zhixue, HOU Xiaodan, JIN Xinyuan, SONG Mingming, LIU Xia, YANG Yili. Function and clinical role of serum orosomucoid[J]. Laboratory Medicine, 2018, 33(10): 943-948.

图/表 4

参考文献 30

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血清类黏蛋白的功能和临床意义

Function and clinical role of serum orosomucoid

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