关键词: C反应蛋白, 肝素结合蛋白, C反应蛋白/淋巴细胞比值, 肝素结合蛋白/白蛋白比值, 血流感染

Abstract:

Objective To evaluate the diagnostic roles of C-reactive protein （CRP），heparin-binding protein （HBP），C-reactive protein to lymphocyte ratio （CLR），heparin-binding protein to albumin ratio （HAR） in elderly patients with bloodstream infection （BSI）. Methods A total of 84 patients with BSI positive blood culture （without other types of infections）89 suspected BSI patients with negative blood culture （without other types of infections） in Huadong Hospital of Fudan University from January to December 2023 were enrolled as positive and negative blood culture group，respectively. The levels of CRP，HBP，CLR and HAR were compared between the 2 groups. Binary Logistic regression analysis and receiver operating characteristic （ROC） curve were used to analyze the auxiliary diagnostic value of each index in BSI. Results The levels of CRP，HBP，CLR and HAR in positive blood culture group were higher than those in negative blood culture group（P<0.001）. The areas under curves（AUC）of CRP，HBP，CLR and HAR single determinations in the diagnosis of BSI were 0.700，0.748，0.716 and 0.766，respectively. The AUC of HBP+CLR+HAR combined determination was 0.813，the sensitivity was 79.76%，and the specificity was 67.42%. Conclusions The levels of HBP，CLR and HAR in BSI patients are increased，and the combined determination of HBP+CLR+HAR may improve the diagnostic efficiency in the diagnosis of BSI.

Key words: C-reactive protein, Heparin-binding protein, C-reactive protein to lymphocyte ratio, Heparin-binding protein to albumin ratio, Bloodstream infection