糖尿病视网膜病变患者血清胎球蛋白A水平的变化及其与CRP的相关性

doi:10.3969/j.issn.1673-8640.2014.10.012

检验医学 ›› 2014, Vol. 29 ›› Issue (10): 1034-1036.DOI: 10.3969/j.issn.1673-8640.2014.10.012

糖尿病视网膜病变患者血清胎球蛋白A水平的变化及其与CRP的相关性

周中卫¹, 孙明忠¹, 居会祥¹, 季禹乔¹, 顾娟¹, 季飞², 丁福万³, 江冬梅³

1.东南大学医学院附属盐城医院检验科,江苏盐城 224001;
2.东南大学医学院附属盐城医院眼科,江苏盐城 224001;
3. 东南大学医学院附属盐城医院内分泌科,江苏盐城 224001

收稿日期:2014-07-10 出版日期:2014-10-30 发布日期:2014-10-22
作者简介:周中卫,男,1975年生,硕士,主管技师,主要从事临床生化及分子生物学研究。

The changes of serum alpha2-Heremans-Schmid glycoprotein level and its correlation with CRP in patients with diabetic retinopathy

ZHOU Zhongwei¹, SUN Mingzhong¹, JU Huixiang¹, JI Yuqiao¹, GU Juan¹, JI Fei², DING Fuwan³, JIANG Dongmei³

1.Department of Clinical Laboratory, Yancheng Hospital, Southeast University School of Medicine, Jiangsu Yancheng 224001, China;
2. Department of Ophthalmology, Yancheng Hospital, Southeast University School of Medicine, Jiangsu Yancheng 224001, China;
3. Department of Endocrinology, Yancheng Hospital, Southeast University School of Medicine, Jiangsu Yancheng 224001, China

Received:2014-07-10 Online:2014-10-30 Published:2014-10-22

摘要/Abstract

摘要： 目的探讨糖尿病视网膜病变(DR)患者血清胎球蛋白A(AHSG)水平的变化及其与C反应蛋白(CRP)的相关性。方法选取2型糖尿病(T2DM)患者115例,分为糖尿病无视网膜病变(NDR)组46例、非增生性糖尿病视网膜病变(NPDR)组37例、增生性糖尿病视网膜病变(PDR)组32例;另选取正常对照组40名。采用酶联免疫吸附试验(ELISA)测定血清AHSG与CRP水平。结果 NDR组、NPDR组及PDR组血清AHSG及CRP水平均高于正常对照组,组间比较及组内两两比较差异均有统计学意义(P<0.05,P<0.01)。T2DM患者的血清AHSG水平与CRP呈正相关(r=0.239,P<0.05)。结论 AHSG水平升高与DR的病情严重程度有关,其可能通过促炎性效应参与DR的发生、发展。

关键词: 糖尿病视网膜病变, 胎球蛋白A, C反应蛋白

Abstract: Objective To investigate the changes of serum alpha2-Heremans-Schmid glycoprotein(AHSG)level and its correlation with C-reactive protein (CRP) in patients with diabetic retinopathy (DR). Methods Serum levels of AHSG and CRP were determined by enzyme-linked immunosorbent assay (ELISA) in 115 type 2 diabetes mellitus(T2DM) patients, and the 115 T2DM patients were classified into 3 groups, 46 patients with non-diabetic retinopathy(NDR), 37 patients with non-proliferative diabetic retinopathy (NPDR) and 32 patients with proliferative diabetic retinopathy (PDR). A total of 40 healthy controls were enrolled. Resutls The serum levels of AHSG and CRP in NDR group, NPDR group and PDR group were higher than that in healthy control group, and there was statistical significance among the groups(P<0.05, P<0.01). Serum AHSG level in T2DM patients was positively correlated with CRP (r=0.239, P<0.05). Conclusions The increasing of AHSG level is correlated with the severity of DR, and it may be involved in the development and pathogenesis of DR by proinflammatory effects.

Key words: Diabetic retinopathy, Alpha2-Heremans-Schmid glycoprotein, C-reactive protein

中图分类号:

R446.1

周中卫, 孙明忠, 居会祥, 季禹乔, 顾娟, 季飞, 丁福万, 江冬梅. 糖尿病视网膜病变患者血清胎球蛋白A水平的变化及其与CRP的相关性[J]. 检验医学, 2014, 29(10): 1034-1036.

ZHOU Zhongwei, SUN Mingzhong, JU Huixiang, JI Yuqiao, GU Juan, JI Fei, DING Fuwan, JIANG Dongmei. The changes of serum alpha2-Heremans-Schmid glycoprotein level and its correlation with CRP in patients with diabetic retinopathy[J]. , 2014, 29(10): 1034-1036.

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糖尿病视网膜病变患者血清胎球蛋白A水平的变化及其与CRP的相关性

The changes of serum alpha2-Heremans-Schmid glycoprotein level and its correlation with CRP in patients with diabetic retinopathy

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