关键词: 血浆纤维蛋白原γ链, 子痫前期, 片段, 预测, 辅助诊断

Abstract: Objective To investigate the levels of fibrinogen γ and its products in plasma of preeclampsia pregnant women, and to study the predictive and aided diagnosis significance in preeclampsia. Methods The clinical data of human chorionic gonadotropin(HCG)-positive pregnant women were followed and collected until delivery, and the plasma specimens were collected. The levels of fibrinogen γ were measured by Western blotting in 31 patients with preeclampsia (15 patients with mild preeclampsia and 16 patients with severe preeclampsia) and 31 healthy controls being enrolled randomly. Results The levels of fibrinogen γ had no statistical significance in plasma of healthy controls during pregnancy(P>0.05). The levels of fibrinogen γ in plasma of patients on 2-7 weeks before the onset of preeclampsia began to rise, and it rose more when preeclampsia happened(P<0.05). Three fibrinogen γ fragments, 25 000, 27 000 and 23 000, appeared in plasma of 1 patient on 2 weeks before preeclampsia happened and 3 patients when preeclampsia happened in 16 patients who developed severe preeclampsia.These fragments appeared in only 1 patient in 15 patients who developed mild preeclampsia. These fragments did not appear in 31 healthy controls. Conclusions Patients before and after the onset of preeclampsia have a synthesis and degradation fibrinogen γ disorder. The synthesis of fibrinogen γ increases, and fibrinogen γ fragments, 25 000, 27 000 and 23 000, appear when fibrinogen γ degradated in some patients. The levels of fibrinogen γ and these fragments may have some significance for predicting and diagnosing preeclampsia.

Key words: Plasma fibrinogen γ, Preeclampsia, Fragment, Prediction, Aided diagnosis