检验医学 ›› 2013, Vol. 28 ›› Issue (2): 137-139.DOI: 10.3969/j.issn.1673-8640.2013.02.013

• 临床应用研究.论著 • 上一篇    下一篇

确山县HIV单阳家庭HCV及梅毒螺旋体感染情况调查

王鹏1,肖青2,泰淑红1,杨四梅2,薛喜梅2,宋俊华3,贾莉婷1   

  1. 1.郑州大学第三附属医院检验科,河南 郑州 450052;2.确山县疾病预防控制中心,河南 确山 463200;3.新乡市第二人民医院,河南 新乡 453000
  • 收稿日期:2012-11-28 修回日期:2012-06-13 出版日期:2013-02-28 发布日期:2013-01-28
  • 通讯作者: 贾莉婷,联系电话:0371-66903509。
  • 作者简介:王鹏,男,1981年生,硕士,主管技师,主要从事临床免疫学检验工作。

The infection of hepatitis C virus and treponema pallidum among HIV single-infection couples in Queshan county

  1. 1.Department of Clinical Laboratory,the Third Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450052,China;2.The Queshan Center for Disease Control and Prevention,Henan Queshan 463200,China;3.The Second People′s Hospital of Xinxiang,Henan Xinxiang 453000,China
  • Received:2012-11-28 Revised:2012-06-13 Online:2013-02-28 Published:2013-01-28

摘要: 目的 了解确山县人类免疫缺陷病毒(HIV)单阳家庭感染丙型肝炎病毒(HCV)及梅毒螺旋体的情况。 方法 以确山县362户HIV单阳家庭夫妻双方为实验组,完成HIV阳性配偶采样169例,完成HIV阴性配偶采样339例。采用酶联免疫吸附试验(ELISA)检测血清中HCV抗体及梅毒螺旋体抗体。以确山县本地医院同期进行健康体检者1 700名作为正常对照。 结果 单阳家庭169例HIV阳性者HCV抗体阳性145例,阳性率85.8%,明显高于HIV阴性者HCV抗体阳性率[34.8%(118/339),χ2=117.4,P<0.01];以上2组人群HCV感染率均较正常对照组[4.6%(78/1 700)]明显升高(χ2=891.3,P<0.01)。以家庭为单位,单阳家庭HCV感染率为91.1%。单阳家庭夫妻双方梅毒螺旋体感染率与正常对照组比较,差异无统计学意义(χ2=1.764,P>0.05)。 结论 确山县HIV单阳家庭HIV的传播途径仍以血液途径为主,在预防HIV传播的同时应注意预防HCV的合并感染。

关键词: 人类免疫缺陷病毒, 单阳家庭, 丙型肝炎病毒, 梅毒螺旋体

Abstract: Objective To understand the infection of hepatitis C virus(HCV) and treponema pallidum among human immunodeficiency virus(HIV) single-infection couples in Queshan county.   Methods A total of 362 HIV single-infection couples in Queshan county were enrolled as experiment group. The blood of 169 HIV-positive spouses and 339 HIV-negative spouses had been extracted. The anti-HCV and anti-treponema pallidum antibodies had been detected by enzyme-linked immunosorbent assay(ELISA). The 1 700 healthy subjects in local hospital were enrolled as healthy controls. Results The HCV infection rate of the HIV-positive spouses was 85.8%(145/169).It was significantly higher than that of HIV-negative spouses[34.8%(118/339),χ2=117.4,P<0.01]. The HCV infection rates of the 2 groups were higher than that of control group [4.6%(78/1 700),χ2=891.3,P<0.01]. The HCV infection rate of HIV single-infection couples was 91.1%. The difference of treponema pallidum incidence was not significant between experiment group and control group(χ2=1.764,P>0.05). Conclusions It is indicated that blood is the main route of HIV infection among HIV single-infection couples in Queshan county,and the HCV concurrent infection should be paid attention while preventing the pathophoresis of HCV.

Key words: Human immunodeficiency virus, Single-infection couple, Hepatitis C virus, Treponema pallidum