Objective To investigate the correlation of the changes of serum alpha2-Heremans-Schmid glycoprotein（AHSG）levels with metabolic syndrome（MS）. Methods A total of 726 subjects were enrolled. Their clinical data [waist circumference, blood pressure,body mass index（BMI）, fasting plasma glucose（FPG）, total cholesterol （TC）, triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,C-reactive protein（CRP）,homeostasis model assessment for insulin resistance（HOMA-IR）and free fatty acid（FFA）] were collected,and serum levels of AHSG were determined by enzyme-linked immunosorbent assay. A total of 211 of 726 subjects were identified with MS,according to the revision of the Adult Treatment Panel Ⅲ of the National Cholesterol Education Program（NCEP-ATP Ⅲ）in 2005. The parameters were compared between MS and non-MS groups. The relation between AHSG and parameters was analyzed by Pearson correlation analysis and multiple linear regression analysis. The quartiles of AHSG and the relative risk of MS were evaluated by Logistic regression analysis,and receiver operating characteristic（ROC）curve was used to assess the role of AHSG for the diagnosis of MS. Results Serum AHSG level was higher in MS group than that in non-MS group（P<0.05）,and there was statistical significance for the other parameters between the 2 groups（P<0.05,P<0.01）. AHSG was positively correlated with waist circumference,FPG,TG,LDL-C,CRP,HOMA-IR and FFA（r=0.094,0.133,0.107,0.078,0.088,0.126 and 0.119,P<0.05）,and was correlated independently with waist circumference, CRP and HOMA-IR（β=0.088, 0.083 and 0.091, P=0.022, 0.033 and 0.014）. The risk of MS increased with increasing quartiles of AHSG in Logistic regression analysis（P<0.01）. ROC curve showed that the area under the curve was 0.709,and the cut-off value was 285.3 μg/mL. The sensitivity was 70.5%,and the specificity was 73.8%. Conclusions Increased AHSG level is one of risk factors for MS,and it plays a role for predicting the incidence of MS.
