Abstract:

Objective To investigate human papillomavirus（HPV）infection and subtype distribution in Shanghai Songjiang,to analyze HPV pathogenicity on cervical cells,and to provide a reference for the control and prevention of cervical cancer. Methods A total of 5 039 female outpatients' cervical secretion samples from Shanghai Songjiang Central Hospital were collected from February 1st to March 31st in 2016. HPV genotyping was performed,and the subtype distribution in different ages was analyzed. HPV pathogenicity on cervical cells was evaluated. Results There were 1 140 positive samples,including 798 cases of single infection and 342 cases of multiple infection,and the infection rate was 22.6%. The infection rates were 29.5% in < 20-year-old group,21.0% in 21-30-year-old group,21.7% in 31-40-year-old group,21.7% in 41-50-year-old group,30.0% in 51-60-year-old group and 28.8% in >60-year-old group（P=0.000 161）. The top 5 subtypes were type 16（17.0%）, 52（14.6%）, 58（12.8%）, 54（8.2%）and 51（8.2%）. The proportion of lesion ≥ atypical squamous cells of undetermined significance （ASCUS）in high-risk HPV group（HPV type 16 and 18）was higher than those in low-risk HPV group（other subtypes,except HPV type 16 and 18）and negative control group（P<0.05）. Conclusions HPV infection rate in 51-60-year-old group is the highest in Shanghai Songjiang. HPV type 16 or 18 is more likely to cause cervical cell lesion. HPV screening for high-risk population is helpful for the prevention and treatment of cervical cancer.

Key words: Human papillomavirus, Infection rate, Subtype, Age distribution, Pathogenicity, Songjiang