Abstract:

Objective To evaluate the roles of platelet （PLT）parameters and bone marrow megakaryocyte count and classification in May-Hegglin anomaly（MHA）and primary immune thrombocytopenia（ITP）. Methods A total of 88 patients with acute and chronic primary ITP were enrolled,there were 15 patients with MHA,and 40 healthy subjects were enrolled as control group. They were classified into 4 groups,and megakaryocyte count and classification and 4 parameters of PLT [PLT count,plateletcrit（PCT）,mean platelet volume（MPV）and platelet volume distribution width（PDW）] were determined. Results PDW and MPV were higher in MHA group than those in acute and chronic primary ITP group and control group（P<0.05）. There was statistical significance for megakaryocyte count and classification in MHA group compared with those in acute and chronic primary ITP group （P<0.05）,and there was no statistical significance compared with control group （P>0.05）. Conclusions MPV and PDW play roles in the diagnosis of MHA. Megakaryocyte count and classification can identify MHA and acute and chronic primary ITP.

Key words: May-Hegglin anomaly, Megakaryocyte, Primary immune thrombocytopenia, Platelet parameter