Abstract:

Objective To investigate the significance of platelet（PLT） parameters [PLT count, plateletcrit（PCT）,platelet distribution width（PDW）,mean platelet volume（MPV） and platelet-large cell rate（P-LCR）] for the cause analysis of thrombocytopenia.Methods A total of 139 children with thrombocytopenia were enrolled. There were 48 cases of idiopathic thrombocytopenic purpura（ITP）,19 cases of aplastic anemia（AA）,9 cases of acute leukemia（AL）,27 cases of extramedullary tumors [neuroblastoma (N) and hepatoblastoma（H）] and 36 cases of acute infections（INF）. A total of 84 healthy children were enrolled as healthy control group. PLT parameters were analyzed statistically. Results There was consistency of PLT count and PCT,and MPV and P-LCR had consistency. MPV had independence. PLT count and PCT in thrombocytopenia group were lower than those in healthy control group（P<0.05）. MPV and P-LCR in thrombocytopenia group were higher than those in healthy control group（P<0.05）. Except for AL group,PDW in the other groups had statistical significance with that in healthy control group（P<0.05）. PLT count and PCT in INF group were higher than those in the other groups（P<0.05）. PDW,MPV and P-LCR in INF group were lower than those in ITP and AA groups（P<0.05）. Conclusions There are different characteristics of PLT parameters in different groups. It has a certain significance of PLT count and PLT parameters for the cause analysis of thrombocytopenia.

Key words: Platelet parameters, Thrombocytopenia, Cause analysis