Establishment of reference intervals for renal function parameters in middle and late pregnancy

doi:10.3969/j.issn.1673-8640.2017.08.005

Abstract

Abstract:

Objective To investigate the renal function parameters [urea,creatinine（Cr）,uric acid（UA）,urea/Cr ratio and UA/Cr ratio] during healthy pregnancy,and to establish the reference intervals for renal function parameters in middle and late pregnancy. Methods The levels of urea,Cr and UA were determined in 4 000 healthy pregnant women（pregnancy group）and 4 000 healthy women of childbearing age（healthy control group）. For pregnancy group,urea,Cr and UA levels were determined at 14-20,24-28 and 37-40 gestational weeks．The reference intervals in middle and late pregnancy were defined as the 2.5th percentile （P_2.5）- the 97.5th percentile （P_97.5）. Results The levels of urea and Cr in pregnancy group were lower than those in healthy control group（P<0.05）,and the levels of UA at 14-20 and 24-28 gestational weeks were lower than those in healthy control group（P<0.05）. The levels of UA in 37-40 gestational weeks were higher than those in healthy control group（P<0.05）.Compared with healthy control group,serum urea/Cr ratio in pregnancy group decreased to various degrees at 14-20 and 24-28 gestational weeks（P<0.05）,and then increased at 37-40 gestational weeks（P>0.05）．Serum UA/Cr ratio in pregnancy group decreased at 14-20 gestational weeks,and then increased with the progression of gestational weeks（P<0.05）．The reference intervals of renal function parameters at 14-20,24-28 and 37-40 gestational weeks were 1.8-3.9,1.7-3.8,1.7-5.0 mmol/L for urea,33-53,32-54,31-60 μmol/L for Cr,141-269,127-352,161-457 μmol/L for UA,43.66-92.71,39.97-97.37,36.44-124.04 for urea/Cr ratio,and 3.15-6.25,3.17-8.55,3.18-11.20 for UA/Cr ratio. Conclusions There are different degrees of physiological changes of renal function in pregnant women with the progression of pregnancy,so it should establish the reference intervals of renal function parameters in middle and late pregnancy.

Key words: Urea, Creatinine, Uric acid, Pregnancy, Reference interval

CLC Number:

R446.1

XU Liyuan, YING Chunmei. Establishment of reference intervals for renal function parameters in middle and late pregnancy[J]. Laboratory Medicine, 2017, 32(8): 682-685.

Figures/Tables 2

References 11

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组别	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	尿素/Cr比值	UA/Cr比值
正常对照组	3.9（3.3~4.3）	50（46~54）	254（222~301）	76.23（64.43~90.17）	5.12（4.30~5.76）
妊娠组
孕14~20周	2.7（2.4~3.1）^*	42（39~45）^*	199（178~223）^*	65.12（55.32~73.53）^*	4.65（4.13~5.18）^*
孕24~28周	2.6（2.2~3.1）^*	41（38~45）^*	234（206~275）^*#	64.84（54.75~75.63）^*	5.77（4.89~6.55）^*#
孕37~40周	3.3（2.7~3.8）^*#△	44（39~49）^*#△	294（254~351）^*#△	72.73（58.28~89.68）^#△	6.80（5.33~8.18）^*#△

组别	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	尿素/Cr比值	UA/Cr比值
正常对照组	3.9（3.3~4.3）	50（46~54）	254（222~301）	76.23（64.43~90.17）	5.12（4.30~5.76）
妊娠组
孕14~20周	2.7（2.4~3.1）^*	42（39~45）^*	199（178~223）^*	65.12（55.32~73.53）^*	4.65（4.13~5.18）^*
孕24~28周	2.6（2.2~3.1）^*	41（38~45）^*	234（206~275）^*#	64.84（54.75~75.63）^*	5.77（4.89~6.55）^*#
孕37~40周	3.3（2.7~3.8）^*#△	44（39~49）^*#△	294（254~351）^*#△	72.73（58.28~89.68）^#△	6.80（5.33~8.18）^*#△

组别	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	尿素/Cr比值	UA/Cr比值
正常对照组	2.5~5.5	37~64	163~382	44.03~115.70	3.39~7.23
妊娠组
孕14~20周	1.8~3.9	33~53	141~269	43.66~92.71	3.15~6.25
孕24~28周	1.7~3.8	32~54	127~352	39.97~97.37	3.17~8.55
孕37~40周	1.7~5.0	31~60	161~457	36.44~124.04	3.18~11.20

组别	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	尿素/Cr比值	UA/Cr比值
正常对照组	2.5~5.5	37~64	163~382	44.03~115.70	3.39~7.23
妊娠组
孕14~20周	1.8~3.9	33~53	141~269	43.66~92.71	3.15~6.25
孕24~28周	1.7~3.8	32~54	127~352	39.97~97.37	3.17~8.55
孕37~40周	1.7~5.0	31~60	161~457	36.44~124.04	3.18~11.20

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