Role of serum adiponectin determination combined with leptin in the diagnosis of lupus nephritis

doi:10.3969/j.issn.1673-8640.2019.05.004

Abstract

Abstract:

Objective To investigate the role of serum adiponectin determination combined with leptin in the diagnosis of lupus nephritis （LN）. Methods A total of 84 female patients with systemic lupus erythematosus （SLE） were enrolled and classified into LN group （38 cases） and non-LN group （46 cases） according to be with or without renal damage. Totally,45 female healthy subjects were enrolled as healthy control group. Creatinine,white blood cell count and 24 h urinary protein were determined,and serum levels of leptin and adiponectin were determined by enzyme-linked immunosorbent assay. Results Serum levels of leptin and adiponectin in LN group were （34.12±21.41） ng/mL and （21.62±9.69） μg/mL,which were higher than those in healthy control group [（17.21±16.43） ng/mL and （11.31±6.45） μg/mL] （P<0.05）. Serum level of adiponectin in LN group was higher than that in non-LN group [（15.28±5.43） μg/mL] （P<0.05）. The sensitivity and specificity of leptin determination in the diagnosis of LN were 63.16% and 54.35%,respectively. The sensitivity and specificity of adiponectin in the diagnosis of LN were 81.58% and 28.26%,respectively. The sensitivity and specificity of the combined determination of leptin and adiponectin in the diagnosis of LN were 97.37% and 19.57%,respectively. Conclusions Serum adiponectin determination combined with leptin has high sensitivity in the diagnosis of LN,and it can provide a reference for the early diagnosis of LN.

Key words: Leptin, Adiponectin, Lupus nephritis, Systemic lupus erythematosus

CLC Number:

R446.1

XU Liming, SHEN Jun. Role of serum adiponectin determination combined with leptin in the diagnosis of lupus nephritis[J]. Laboratory Medicine, 2019, 34(5): 401-404.

Figures/Tables 7

References 16

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组别	例数	年龄（岁）	身高（cm）	体质量（kg）	心率（次/min）	收缩压（kPa）	体质量指数
LN组	38	33.93±12.15	164.21±5.22	59.13±6.19	73.21±4.33	11.75±0.67	23.67±3.39
非LN组	46	31.72±13.13	162.53±3.77	61.34±5.93	74.22±5.53	11.48±0.93	23.44±4.32
正常对照组	45	33.30±11.90	161.78±5.83	61.47±6.23	72.93±5.52	11.49±0.71	24.92±4.62
F值		0.009	0.059	0.043	0.017	0.033	0.037
P值		0.991	0.943	0.958	0.983	0.968	0.964

组别	例数	年龄（岁）	身高（cm）	体质量（kg）	心率（次/min）	收缩压（kPa）	体质量指数
LN组	38	33.93±12.15	164.21±5.22	59.13±6.19	73.21±4.33	11.75±0.67	23.67±3.39
非LN组	46	31.72±13.13	162.53±3.77	61.34±5.93	74.22±5.53	11.48±0.93	23.44±4.32
正常对照组	45	33.30±11.90	161.78±5.83	61.47±6.23	72.93±5.52	11.49±0.71	24.92±4.62
F值		0.009	0.059	0.043	0.017	0.033	0.037
P值		0.991	0.943	0.958	0.983	0.968	0.964

组别	例数	瘦素（ng/mL）	脂联素（μg/mL）	白细胞计数（×10⁹/L）	肌酐（μmol/L）	24 h定量尿蛋白（g）
LN组	38	34.12±21.41	21.62±9.69	2.11±0.41	470±120	5.34±1.74
非LN组	46	22.50±20.31	15.28±5.43	2.62±0.79	280±80	4.21±1.92
t值		1.089	2.631	4.494	1.859	1.474
P值		0.795	0.002	0.000	0.048	0.228

组别	例数	瘦素（ng/mL）	脂联素（μg/mL）	白细胞计数（×10⁹/L）	肌酐（μmol/L）	24 h定量尿蛋白（g）
LN组	38	34.12±21.41	21.62±9.69	2.11±0.41	470±120	5.34±1.74
非LN组	46	22.50±20.31	15.28±5.43	2.62±0.79	280±80	4.21±1.92
t值		1.089	2.631	4.494	1.859	1.474
P值		0.795	0.002	0.000	0.048	0.228

组别	例数	瘦素（ng/mL）	脂联素（μg/mL）	白细胞计数（×10⁹/L）	肌酐（μmol/L）	24 h定量尿蛋白（g）
LN组	38	34.12±21.41	21.62±9.69	2.11±0.41	470±120	5.34±1.74
正常对照组	45	17.21±16.43	11.31±6.45	6.33±0.87	110±20	0.71±0.23
t值		2.009	1.864	5.451	29.740	47.280
P值		0.018	0.047	0.000	0.000	0.000