Abstract:

Objective To investigate the relationship between parathyroid hormone （PTH） level and renal function in patients with chronic kidney disease （CKD）. Methods A total of 149 patients with CKD were enrolled. According to the staging method of chronic renal failure in China,the CKD patients were classified into 4 groups（chronic renal insufficiency decompensated stage,chronic renal insufficiency compensated stage,chronic renal failure and uremia groups）. Totally,25 healthy subjects were enrolled as healthy control group. PTH levels and biochemical indexes were compared and analyzed,and correlation analysis was conducted. Results Serum PTH,blood urea nitrogen （BUN）,creatinine（Cr）,cystatin C（Cys C） and phosphorus（P） levels in CKD group were higher than those in healthy control group （P<0.05）,and they were gradually increased with CKD stages （P<0.05）. There was no statistical significance for serum calcium（Ca）（P>0.05）. Pearson correlation analysis showed that PTH was positively correlated with BUN,Cr,Cys C and P（r=0.422,0.616,0563 and 0.376,P<0.01）,and it was negatively correlated with Ca（r=-0.332,P<0.01）. Conclusions PTH could reflect the progress of CKD to some extent. Monitoring serum PTH level of patients with chronic renal failure may be helpful to understand the disease progress and evaluate the disease severity.

Key words: Parathyroid hormone, Chronic kidney disease, Chronic renal failure