Laboratory Medicine ›› 2018, Vol. 33 ›› Issue (11): 969-974.DOI: 10.3969/j.issn.1673-8640.2018.011.001
• Orginal Article • Next Articles
SONG Rui, YE Ping, CHEN Xiaoxiang
Received:
2017-09-20
Online:
2018-11-30
Published:
2018-11-28
CLC Number:
SONG Rui, YE Ping, CHEN Xiaoxiang. Correlations between IgG,IgM and IgA anti-ds-DNA antibodies and systemic lupus erythematosus[J]. Laboratory Medicine, 2018, 33(11): 969-974.
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组别 | 例数 | IgG型 | IgM型 | IgA型 |
---|---|---|---|---|
SLE组 | 202 | 54.78(8.86~280.80)* | 13.54(1.96~55.65)*△ | 29.32(8.86~72.58)*△▲ |
SLE活动组 | 112 | 143.7(38.56~1 144.00)*# | 28.99(5.26~67.47)*# | 54.60(27.11~112.10)*# |
SLE缓解组 | 90 | 10.98(1.84~64.19)* | 4.14(0.97~23.21* | 10.68(4.25~26.73)* |
正常对照组 | 53 | 2.67(1.62~3.82) | 1.04(0.44~2.41) | 4.86(3.45~10.28) |
组别 | 例数 | IgG型 | IgM型 | IgA型 |
---|---|---|---|---|
SLE组 | 202 | 54.78(8.86~280.80)* | 13.54(1.96~55.65)*△ | 29.32(8.86~72.58)*△▲ |
SLE活动组 | 112 | 143.7(38.56~1 144.00)*# | 28.99(5.26~67.47)*# | 54.60(27.11~112.10)*# |
SLE缓解组 | 90 | 10.98(1.84~64.19)* | 4.14(0.97~23.21* | 10.68(4.25~26.73)* |
正常对照组 | 53 | 2.67(1.62~3.82) | 1.04(0.44~2.41) | 4.86(3.45~10.28) |
组别 | 例数 | IgG型 | IgM型 | IgA型 | |||
---|---|---|---|---|---|---|---|
阳性 | 阴性 | 阳性 | 阴性 | 阳性 | 阴性 | ||
SLE组 | 202 | 133(65.8) | 69(34.2) | 112(55.5) | 90(44.5) | 119(58.9) | 83(41.1) |
SLE活动组 | 112 | 95(47.0) | 17(8.4) | 64(31.7) | 29(14.3) | 91(45.0) | 21(10.4) |
SLE缓解组 | 90 | 38(18.8) | 52(25.8) | 48(23.8) | 61(30.2) | 28(13.9) | 62(30.7) |
正常对照组 | 53 | 0(0.0) | 53(100.0) | 2(4.0) | 51(96.0) | 2(4.0) | 51(96.0) |
组别 | 例数 | IgG型 | IgM型 | IgA型 | |||
---|---|---|---|---|---|---|---|
阳性 | 阴性 | 阳性 | 阴性 | 阳性 | 阴性 | ||
SLE组 | 202 | 133(65.8) | 69(34.2) | 112(55.5) | 90(44.5) | 119(58.9) | 83(41.1) |
SLE活动组 | 112 | 95(47.0) | 17(8.4) | 64(31.7) | 29(14.3) | 91(45.0) | 21(10.4) |
SLE缓解组 | 90 | 38(18.8) | 52(25.8) | 48(23.8) | 61(30.2) | 28(13.9) | 62(30.7) |
正常对照组 | 53 | 0(0.0) | 53(100.0) | 2(4.0) | 51(96.0) | 2(4.0) | 51(96.0) |
组别 | 例数 | 抗核小体抗体 | 抗核抗体 | 蛋白尿 | 补体降低 | 白细胞减少 | 血小板减少 | 外周关节炎 |
---|---|---|---|---|---|---|---|---|
SLE活动组 | 112 | |||||||
阳性 | 75(67.0) | 111(99.1) | 70(62.5) | 95(84.8) | 29(25.9) | 20(17.8) | 45(40.2) | |
阴性 | 37(33.0) | 1(0.9) | 42(37.5) | 17(15.2) | 83(74.1) | 92(82.1) | 67(59.8) | |
SLE缓解组 | 90 | |||||||
阳性 | 27(30.0) | 79(87.8) | 8(8.9) | 19(21.1) | 3(3.3) | 7(7.8) | 2(2.2) | |
阴性 | 63(70.0) | 11(12.2) | 82(91.1) | 71(78.9) | 87(96.7) | 83(92.2) | 88(97.8) | |
χ2值 | 27.28 | 9.53 | 60.51 | 82.38 | 17.39 | 4.38 | 38.17 | |
P 值 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | 0.04 | <0.01 | |
组别 | 颊部红斑 | 口鼻黏膜溃疡 | 血尿 | 脱发 | 胸膜炎 | 精神症状 | 发热 | 血管炎 |
SLE活动组 | ||||||||
阳性 | 52(46.4) | 17(15.2) | 5(4.5) | 21(18.8) | 11(9.8) | 4(3.6) | 20(17.9) | 2(1.8) |
阴性 | 60(53.6) | 95(84.8) | 107(95.5) | 91(81.3) | 101(90.2) | 108(96.4) | 92(82.1) | 110(98.2) |
SLE缓解组 | ||||||||
阳性 | 14(15.6) | 1(1.1) | 0(0.0) | 4(4.4) | 1(1.1) | 0(0.0) | 6(6.7) | 0(0.0) |
阴性 | 76(84.4) | 89(98.9) | 90(100.0) | 86(95.6) | 89(98.9) | 90(100.0) | 84(93.3) | 90(100.0) |
χ2值 | 21.62 | 10.50 | 2.48 | 8.14 | 5.31 | 1.70 | 5.57 | 0.31 |
P 值 | <0.01 | <0.01 | 0.12 | <0.01 | 0.02 | 0.19 | 0.02 | 0.58 |
组别 | 例数 | 抗核小体抗体 | 抗核抗体 | 蛋白尿 | 补体降低 | 白细胞减少 | 血小板减少 | 外周关节炎 |
---|---|---|---|---|---|---|---|---|
SLE活动组 | 112 | |||||||
阳性 | 75(67.0) | 111(99.1) | 70(62.5) | 95(84.8) | 29(25.9) | 20(17.8) | 45(40.2) | |
阴性 | 37(33.0) | 1(0.9) | 42(37.5) | 17(15.2) | 83(74.1) | 92(82.1) | 67(59.8) | |
SLE缓解组 | 90 | |||||||
阳性 | 27(30.0) | 79(87.8) | 8(8.9) | 19(21.1) | 3(3.3) | 7(7.8) | 2(2.2) | |
阴性 | 63(70.0) | 11(12.2) | 82(91.1) | 71(78.9) | 87(96.7) | 83(92.2) | 88(97.8) | |
χ2值 | 27.28 | 9.53 | 60.51 | 82.38 | 17.39 | 4.38 | 38.17 | |
P 值 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | 0.04 | <0.01 | |
组别 | 颊部红斑 | 口鼻黏膜溃疡 | 血尿 | 脱发 | 胸膜炎 | 精神症状 | 发热 | 血管炎 |
SLE活动组 | ||||||||
阳性 | 52(46.4) | 17(15.2) | 5(4.5) | 21(18.8) | 11(9.8) | 4(3.6) | 20(17.9) | 2(1.8) |
阴性 | 60(53.6) | 95(84.8) | 107(95.5) | 91(81.3) | 101(90.2) | 108(96.4) | 92(82.1) | 110(98.2) |
SLE缓解组 | ||||||||
阳性 | 14(15.6) | 1(1.1) | 0(0.0) | 4(4.4) | 1(1.1) | 0(0.0) | 6(6.7) | 0(0.0) |
阴性 | 76(84.4) | 89(98.9) | 90(100.0) | 86(95.6) | 89(98.9) | 90(100.0) | 84(93.3) | 90(100.0) |
χ2值 | 21.62 | 10.50 | 2.48 | 8.14 | 5.31 | 1.70 | 5.57 | 0.31 |
P 值 | <0.01 | <0.01 | 0.12 | <0.01 | 0.02 | 0.19 | 0.02 | 0.58 |
临床表现 | IgG型 | IgM型 | IgA型 |
---|---|---|---|
抗核小体抗体阳性 | 6.81(3.47~13.37)** | 2.66(1.51~4.71)** | 6.29(3.36~11.78)** |
抗核抗体阳性 | 25.03(3.16~198.45)** | 4.60(0.98~21.54) | 18.03(2.28~142.58)** |
蛋白尿 | 2.35(1.24~4.44)** | 1.01(0.61~1.67) | 1.70(0.96~3.00) |
补体降低 | 5.91(3.11~11.20)** | 2.19(1.24~3.88)** | 6.22(3.35~22.55)** |
白细胞减少 | 2.55(0.99~6.54) | 2.22(1.02~4.82)* | 2.89(1.19~7.04)* |
血小板减少 | 0.87(0.37~2.01) | 1.31(0.58~2.95) | 1.22(0.53~2.81) |
外周关节炎 | 4.68(1.88~11.68)** | 1.45(0.76~2.80) | 4.57(2.01~10.41)** |
颊部红斑 | 2.24(1.15~4.38)* | 1.27(0.70~2.28) | 1.627(0.88~3.00) |
口鼻黏膜溃疡 | 2.80(0.78~10.01) | 1.96(0.73~5.27) | 2.63(0.84~8.31) |
血尿 | 2.11(0.23~19.24) | 1.78(0.29~10.91) | |
脱发 | 4.36(1.26~15.13)* | 2.31(0.97~5.51) | 1.94(0.77~4.87) |
胸膜炎 | 6.45(1.38~30.22)* | ||
精神症状 | 3.60(0.37~35.21) | 2.12(0.22~20.75) | |
发热 | 1.86(0.71~4.87) | 2.49(1.05~5.88)* | 2.06(0.83~5.16) |
血管炎 |
临床表现 | IgG型 | IgM型 | IgA型 |
---|---|---|---|
抗核小体抗体阳性 | 6.81(3.47~13.37)** | 2.66(1.51~4.71)** | 6.29(3.36~11.78)** |
抗核抗体阳性 | 25.03(3.16~198.45)** | 4.60(0.98~21.54) | 18.03(2.28~142.58)** |
蛋白尿 | 2.35(1.24~4.44)** | 1.01(0.61~1.67) | 1.70(0.96~3.00) |
补体降低 | 5.91(3.11~11.20)** | 2.19(1.24~3.88)** | 6.22(3.35~22.55)** |
白细胞减少 | 2.55(0.99~6.54) | 2.22(1.02~4.82)* | 2.89(1.19~7.04)* |
血小板减少 | 0.87(0.37~2.01) | 1.31(0.58~2.95) | 1.22(0.53~2.81) |
外周关节炎 | 4.68(1.88~11.68)** | 1.45(0.76~2.80) | 4.57(2.01~10.41)** |
颊部红斑 | 2.24(1.15~4.38)* | 1.27(0.70~2.28) | 1.627(0.88~3.00) |
口鼻黏膜溃疡 | 2.80(0.78~10.01) | 1.96(0.73~5.27) | 2.63(0.84~8.31) |
血尿 | 2.11(0.23~19.24) | 1.78(0.29~10.91) | |
脱发 | 4.36(1.26~15.13)* | 2.31(0.97~5.51) | 1.94(0.77~4.87) |
胸膜炎 | 6.45(1.38~30.22)* | ||
精神症状 | 3.60(0.37~35.21) | 2.12(0.22~20.75) | |
发热 | 1.86(0.71~4.87) | 2.49(1.05~5.88)* | 2.06(0.83~5.16) |
血管炎 |
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