Results on lipoprotein（a） determination in external quality assessment

doi:10.3969/j.issn.1673-8640.2017.05.019

Abstract

Abstract:

Objective To analyze the results of lipoprotein（a） [Lp（a）] determination with different methods in Huizhou First People's Hospital Department of Clinical Laboratory participating external quality assessment （EQA） of the National Center for Clinical Laboratories from 2014 to 2016,and to choose effective methods and reduce the possibility of bias. Methodse A total of 25 EQA results of Lp（a）determination in 5 batches from 2014 to 2016 were statistically analyzed by bias,proficiency testing （PT）,Z score and quality control multi-rules. Results The results of bias met the requirements of EQA. PT scores were all 100,and |Z| was <1.0,which meant satisfaction. Quality control multi-rules showed the 1st and 2nd EQA in 2014 and the 2nd EQA in 2015 had at least 1 sample's results exceeding 50% allowable total error （TEa）,and all of them were against the rules of 5+1_50%TEa,which meant that systematic error was existing. Conclusions The results of Lp（a）determination are satisfactory and meet the requirements of the National Center for Clinical Laboratories,which can be further improved. The sensitivity of quality control multi-rules is higher than other indices of EQA.

Key words: External quality assessment, Lipoprotein（a）, Z score, Quality control multi-rules

CLC Number:

R446.1

LEI Yanmei, MA Jianguo, LIU Jihong. Results on lipoprotein（a） determination in external quality assessment[J]. Laboratory Medicine, 2017, 32(5): 431-434.

Figures/Tables 3

References 9

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规则表达式	解释	意义
2/5_1.0SDI	5份EQA样本有2个及以上测定结果SDI超过±1	需进一步分析原因
X_1.5SDI	5份EQA样本测定结果平均SDI超过±1.5	系统误差
1_3.0SDI	5份EQA样本至少有1个测定结果SDI超过±3	随机误差
R_4.0SDI	5份EQA样本任何2份样本SDI之差>4	随机误差
1_75%TEa	5份EQA样本1份结果偏差超过了TEa的75%	不确定
5+1_50%TEa	5份EQA样本测定结果在均值一侧,其中1份结果偏差超过TEa的50%	系统误差

规则表达式	解释	意义
2/5_1.0SDI	5份EQA样本有2个及以上测定结果SDI超过±1	需进一步分析原因
X_1.5SDI	5份EQA样本测定结果平均SDI超过±1.5	系统误差
1_3.0SDI	5份EQA样本至少有1个测定结果SDI超过±3	随机误差
R_4.0SDI	5份EQA样本任何2份样本SDI之差>4	随机误差
1_75%TEa	5份EQA样本1份结果偏差超过了TEa的75%	不确定
5+1_50%TEa	5份EQA样本测定结果在均值一侧,其中1份结果偏差超过TEa的50%	系统误差

标本编号	检测结果（mg/L）	靶值（mg/L）	偏差（%）	结果
201411	191	231.00	-17.37	通过
201412	99	123.00	-19.51	通过
201413	124	145.00	-14.48	通过
201414	114	124.00	-8.06	通过
201415	194	227.00	-14.54	通过
201421	122	140.50	-13.17	通过
201422	160	183.00	-2.57	通过
201423	144	165.50	-12.99	通过
201424	255	308.75	-17.41	通过
201425	132	156.00	-14.74	通过
201511	169	187.00	-9.63	通过
201512	131	141.00	-7.09	通过
201513	146	156.00	-6.41	通过
201514	149	159.00	-6.29	通过
201515	178	196.00	-9.81	通过
201521	118	136.00	-13.24	通过
201522	159	160.00	-0.62	通过
201523	188	191.00	-1.57	通过
201524	155	165.00	-6.06	通过
201525	113	144.00	-21.53	通过
201611	148	171.00	-13.45	通过
201612	106	121.00	-12.40	通过
201613	199	230.00	-14.48	通过
201614	105	117.00	-10.26	通过
201615	188	215.00	-12.56	通过

标本编号	检测结果（mg/L）	靶值（mg/L）	偏差（%）	结果
201411	191	231.00	-17.37	通过
201412	99	123.00	-19.51	通过
201413	124	145.00	-14.48	通过
201414	114	124.00	-8.06	通过
201415	194	227.00	-14.54	通过
201421	122	140.50	-13.17	通过
201422	160	183.00	-2.57	通过
201423	144	165.50	-12.99	通过
201424	255	308.75	-17.41	通过
201425	132	156.00	-14.74	通过
201511	169	187.00	-9.63	通过
201512	131	141.00	-7.09	通过
201513	146	156.00	-6.41	通过
201514	149	159.00	-6.29	通过
201515	178	196.00	-9.81	通过
201521	118	136.00	-13.24	通过
201522	159	160.00	-0.62	通过
201523	188	191.00	-1.57	通过
201524	155	165.00	-6.06	通过
201525	113	144.00	-21.53	通过
201611	148	171.00	-13.45	通过
201612	106	121.00	-12.40	通过
201613	199	230.00	-14.48	通过
201614	105	117.00	-10.26	通过
201615	188	215.00	-12.56	通过

标本编号	检测结果（mg/L）	允许范围（mg/L）	IQR	Z值	评价	同组标准差	SDI
201411	191	162.00~301.00	69.5	-0.8	满意	35	-1.14
201412	99	86.00~160.00	37.0	-0.9	满意	19	-1.30
201413	124	102.00~189.00	43.5	-0.7	满意	22	-0.95
201414	114	87.00~161.00	37.0	-0.4	满意	19	-0.54
201415	194	159.00~295.00	68.0	-0.7	满意	34	-0.97
201421	122	98.30~182.65	42.2	-0.6	满意	21	-0.88
201422	160	128.10~237.90	54.9	-0.6	满意	27	-0.84
201423	144	115.85~215.15	49.7	-0.6	满意	25	-0.87
201424	255	216.13~401.38	92.6	-0.8	满意	46	-1.16
201425	132	109.20~202.80	46.8	-0.7	满意	23	-1.03
201511	169	131.00~243.00	56.0	-0.4	满意	28	-0.64
201512	131	99.00~183.00	42.0	-0.3	满意	21	-0.48
201513	146	109.00~203.00	47.0	-0.3	满意	24	-0.43
201514	149	111.00~207.00	48.0	-0.3	满意	24	-0.42
201515	178	137.00~255.00	59.0	-0.4	满意	30	-0.61
201521	118	95.00~177.00	41.0	-0.6	满意	21	-0.88
201522	159	112.00~208.00	48.0	0.0	满意	24	-0.04
201523	188	134.00~248.00	57.0	-0.1	满意	29	-0.11
201524	155	116.00~215.00	49.5	-0.3	满意	25	-0.40
201525	113	101.00~187.00	43.0	-1.0	满意	22	-1.44
201611	148	120.00~222.00	51.0	-0.6	满意	26	-0.90
201612	106	85.00~157.00	36.0	-0.6	满意	18	-0.83
201613	199	161.00~299.00	69.0	-0.6	满意	35	-0.90
201614	105	82.00~152.00	35.0	-0.5	满意	18	-0.69
201615	188	151.00~280.00	64.5	-0.6	满意	33	-0.83