The correlation of carotid intima-media thickness with homocysteine, lipoprotein(a)and high-sensitivity C-reactive protein

doi:10.3969/j.issn.1673-8640.2014.08.006

Abstract

Abstract: Objective To investigate the correlation of carotid intima-media thickness(CIMT)with homocysteine(Hcy), lipoprotein(a)[Lp(a)] and high-sensitivity C-reactive protein(hs-CRP). Methods A total of 177 healthy subjects were enrolled and classified into high Hcy group (108 subjects)and normal Hcy group(69 subjects) based on Hcy level. Their Lp(a), hs-CRP and CIMT were determined. The differences of Lp(a), hs-CRP and CIMT between the 2 groups were analyzed comparatively. The correlationship of CIMT with Hcy, Lp(a) and hs-CRP was analyzed. The significance of Hcy, Lp (a) and hs-CRP in the diagnosis of carotid artery intima-media thickness incrassation was evaluated by receiver operating characteristic (ROC) curve. Results The serum levels of hs-CRP and CIMT in high Hcy group were significantly higher than those in normal Hcy group(P=0.000), however there was no significant difference for serum level of Lp(a) between the 2 groups (P=0.217). There was a positive correlation of CIMT with Hcy and hs-CRP (r=0.660 and 0.624, P=0.000). There was no correlation between Lp(a) and CIMT(r=0.122, P=0.316). There was a positive correlation between Hcy and hs-CRP(r=0.597, P=0.000). There was no correlation of Lp(a) with Hcy and hs-CRP(r=0.063, P=0.65; r=0.01, P=0.994). As CIMT ≥1.0 mm as the carotid artery intima-media thickness incrassation upper limit, the areas under ROC curves(AUC) of Hcy, hs-CRP and Lp(a) were 0.869 (P=0.000), 0.872 (P=0.000) and 0.512 (P=0.857). Conclusions The correlation of CIMT with Hcy and hs-CRP is significant, and Hcy and hs-CRP play important roles for carotid artery intima-media thickness incrassation.

Key words: Homocysteine, Lipoprotein(a), High-sensitivity C-reactive protein, Carotid intima-media thickness

CLC Number:

R446.1

WANG Guoqiang, GAO Lili, GUO Lijuan. The correlation of carotid intima-media thickness with homocysteine, lipoprotein(a)and high-sensitivity C-reactive protein[J]. , 2014, 29(8): 809-812.

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