Abstract:

Objective To investigate the relationship of serum glycyl-proline dipeptidyl aminopeptidase(GPDA) and upper gastrointestinal bleeding(UGIB). Methods Serum GPDA and urea concentrations were measured in 33 patients with UGIB(UGIB group)and 33 healthy subjects (control group). The UGIB group was classified according sex and age (<60 years old and ≥60 years old). The results were analyzed statisically. Results Serum GPDA and urea concentrations between UGIB group and control group were significant statistically (P=0.000). The concentrations of serum GPDA and urea in different age groups had statistical significance (P<0.01). There was no statistical significance between male and female groups (P>0.05). There was a negative correlation of GPDA and urea concentrations in UGIB group [coefficient of correlation (r)=-0.585, P<0.01]. Receiver operating characteristic (ROC) curve showed that the areas under the ROC curve (AUC) were 0.893 and 0.769 for GPDA and urea. When the cut-off values of GPDA and urea were 69.20 U/L and 8.25 mmol/L, the sensitivities were 97.0% and 63.6%, and the specificities were 69.7% and 97.0%. Conclusions Serum GPDA reduces significantly when UGIB, and GPDA may play an important role in the course of UGIB.

Key words: Glycyl-proline dipeptidyl aminopeptidase, Urea, Upper gastrointestinal bleeding