Abstract:

Objective To analyze the infection status and drug susceptibility of ureaplasma urealyticum（Uu） and mycoplasma hominis（Mh） among patients with urogenital tract infection,and to provide a reference for diagnosis and treatment.Methods Uu and Mh were cultured and identified from 1 638 outpatients with urogenital tract infection from January 2009 to December 2014,and drug susceptibility test was performed simultaneously. Results The positive rate of mycoplasma infection was 45.6%（747/1 638）. The positive rates of Uu and Mh infections were 44.4% and 9.5%,respectively. There were 36.1% patients infected only with Uu,1.2% patients infected only with Mh and 8.4% patients infected with Uu and Mh. The positive rate of mycoplasma infection was higher in females（48.6%） than that in males（20.9%）（P<0.01）. From 2009 to 2013,the positive rate of mycoplasma infection increased in turn from 19.3%,29.3%,41.4%,46.9% to 56.0%. The positive rate of mycoplasma infection in 2014 was 44.2%,which was lower than that in 2013（P<0.05）,which the positive rate of Uu infection decreased,while that of Mh infection increased year by year. The drug susceptibility rates of Uu and Mh to quinolones were the lowest（<20%）,but those to doxycycline,minocycline and josamycine were higher（>70%）.The drug susceptibility rates of Mh to antibiotics were lower than those of Uu. The drug susceptibility rates of Uu and Mh to tetracycline and josamycine in females were higher than those in males.Conclusions The positive rate of Mh infection increases year by year,and patients with Mh infection are often infected with Uu simultaneously. The drug susceptibility of Mh to antibiotics is lower than that of Uu,which would bring challenges to treatment. Therefore,clinicians should pay more attention to it.

Key words: Ureaplasma urealyticum, Mycoplasma hominis, Drug susceptibility test