Abstract:

Objective To analyze the biochemical determination items [urea,creatinine（Cr）,uric acid（UA）,total protein（TP） and albumin（Alb）] for kidney function of 3-17-year-old healthy children in Shanghai,and to establish the reference ranges. Methods A total of 1 038 healthy children aged from 3 to 17 years in Shanghai,including 543 boys and 495 girls,were enrolled. The subjects were classified into 3 groups,including 3-6-year-old group（345 cases）,7-12-year-old group（434 cases） and 13-17-year-old group（259 cases）. Serum urea,Cr,UA,TP and Alb were determined by Hitachi 7180 automatic biochemical analyzer,and the reference ranges were established by x±1.96s. Results Except serum urea,there was statistical significance for serum Cr,UA,TP and Alb in different age groups（P<0.05）,and there was increasing trend with age. There was statistical significance for serum UA and Cr between 7-12-year-old group and 13-17-year-old group（P<0.05）. The reference ranges were established after the analysis of age and sex factors. The reference range of urea was 3.36-5.41 mmol/L （3-17-year-old）. The reference ranges of Cr were 24.47-38.07 μmol/L（3-6-year-old）,33.45-49.27 μmol/L（7-12-year-old boys）,33.09-46.05 μmol/L（7-12-year-old girls）,46.00-70.00 μmol/L（13-17-year-old boys） and 42.67-60.63 μmol/L（13-17-year-old girls）. The reference ranges of UA were 210.00-312.42 μmol/L（3-6-year-old）,216.70-364.58 μmol/L（7-12-year-old boys）,217.27-336.53 μmol/L（7-12-year-old girls）,287.93-474.13 μmol/L（13-17-year-old boys） and 260.39-340.11 μmol/L（13-17-year-old girls）. The reference ranges of TP were 66.23-74.75 g/L（3-6-year-old）,69.12-77.64 g/L（7-12-year-old） and 70.08-78.24 g/L（13-17-year-old）. The reference ranges of Alb were 43.62-48.14 g/L（3-6-year-old）,44.62-48.86 g/L（7-12-year-old） and 45.28-50.28 g/L（13-17-year-old）. Conclusions The reference ranges of biochemical determination items for 3-17-year-old healthy children's kidney function in Shanghai have been preliminarily established.

Key words: Urea, Creatinine, Uric acid, Total protein, Albumin, Reference range