Abstract:

Brucellosis is a serious zoonotic disease，and its diagnosis has always been a difficult problem. With the development of omics research and technology，more and more researches focus on the omics of brucellosis. In terms of genomics，genomic data obtained by sequencing technology can better understand the genetic differences and similarities between strains，so as to type strains，and macro gene sequencing has been applied to the diagnosis of brucellosis in clinical work. In transcriptomics，the transcriptome data of pathogens under specific conditions are obtained by sequencing technology to find biomarkers of value for the diagnosis of brucellosis. In proteomics，the expression，interaction and regulation of proteins in biological processes are studied by mass spectrometry to provide support for new diagnostic methods of brucellosis. In terms of metabolomics，using liquid chromatography tandem mass spectrometry to obtain metabolic profiles of metabolites，analyzing metabolome data can identify metabolic pathways and metabolites，and better understand the metabolic differences between Brucella，which provides a new direction for the diagnosis of Brucella. Finally，the combination of multiple omics can construct more comprehensive and accurate biological information，and provide new ideas and methods for the diagnosis of brucellosis. This review focuses on the application of omics in the diagnosis of brucellosis.

Key words: Brucellosis, Omics, Molecular diagnosis, Multi-omics integration analysis