Application of mean neutrophil volume in severe acute pancreatitis with bacteremia

doi:10.3969/j.issn.1673-8640.2020.07.007

Abstract

Abstract:

Objective To investigate the role of mean neutrophil volume（MNV） in severe acute pancreatitis（SAP） with bacteremia. Methods A total of 48 patients with SAP were enolled. Peripheral blood samples were collected at admission. White blood cell（WBC） count,the absolute value of neutrophil（NEUT#）,MNV,C-reactive protein（CRP） and procalcitonin（PCT） determinations and blood culturing were performed. According to blood culturing results,the patients were classified into 2 groups,SAP with bacteremia group and SAP without bacteremia group. The efficiency of each parameter was analyzed by receiver operating characteristic（ROC） curve. Results CRP and MNV in the 2 groups had statistical significance（P<0.05）. There was no statistical significance in WBC count,NEUT# and PCT between the 2 groups（P>0.05）. ROC curve analysis showed that the area under curve（AUC） of MNV was 0.775,the sensitivity was 84.6%,the specificity was 66.7%,and the optimal cut-off value was 160.5. The AUC of CRP was 0.708,the sensitivity was 92.3%,the specificity was 48.1%,and the optimal cut-off value was 162.5 mg/L. Conclusions MNV may be used in the auxiliary diagnosis of SAP with bacteremia.

Key words: Mean neutrophil volume, Severe acute pancreatitis, Bacteremia, C-reactive protein

CLC Number:

R446.1

LIN Han, SONG Ying, CAI Qi, GUO Ping, CHEN Liting. Application of mean neutrophil volume in severe acute pancreatitis with bacteremia[J]. Laboratory Medicine, 2020, 35(7): 660-662.

Figures/Tables 3

References 10

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组别	例数	WBC计数/（×10⁹/L）	NEUT#/（×10⁹/L）	CRP/（mg/L）	PCT/（ng/mL）	MNV
非感染组	32	10.74±3.60	9.02±3.18	190.52±92.42	0.78（0.49~5.15）	159.81±10.39
感染组	16	12.53±4.57	11.06±4.42	247.27±71.43^*	1.60（0.71~9.59）	168.00±7.53^**

组别	例数	WBC计数/（×10⁹/L）	NEUT#/（×10⁹/L）	CRP/（mg/L）	PCT/（ng/mL）	MNV
非感染组	32	10.74±3.60	9.02±3.18	190.52±92.42	0.78（0.49~5.15）	159.81±10.39
感染组	16	12.53±4.57	11.06±4.42	247.27±71.43^*	1.60（0.71~9.59）	168.00±7.53^**

项目	AUC	最佳临界值	敏感性/%	特异性/%	P值
MNV	0.775	160.5	84.6	66.7	<0.01
CRP	0.708	162.5 mg/L	92.3	48.1	<0.05
PCT	0.584	0.73 ng/mL	76.9	44.4	0.757
WBC计数	0.652	9.775×10⁹/L	76.9	51.9	0.146
NEUT#	0.670	8.525×10⁹/L	69.2	51.9	0.073

项目	AUC	最佳临界值	敏感性/%	特异性/%	P值
MNV	0.775	160.5	84.6	66.7	<0.01
CRP	0.708	162.5 mg/L	92.3	48.1	<0.05
PCT	0.584	0.73 ng/mL	76.9	44.4	0.757
WBC计数	0.652	9.775×10⁹/L	76.9	51.9	0.146
NEUT#	0.670	8.525×10⁹/L	69.2	51.9	0.073

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