Research progress of tigecycline resistance mechanism for Acinetobacter baumannii

doi:10.3969/j.issn.1673-8640.2019.07.019

Abstract

Abstract:

Acinetobacter baumannii is a common opportunistic pathogen causing nosocomial infection. With the wide use of antibiotics,more and more multidrug-resistant Acinetobacter baumannii have been isolated. Tigecycline has been known as the last line of defense against Acinetobacter baumannii. In the recent years,tigecycline-resistant Acinetobacter baumannii has appeared,and its drug resistance mechanism has not yet been fully elucidated. This review focuses on the efflux pump system and new drug resistance mechanisms,including modification enzymes,cell membrane osmosis,DNA damage induction response and target changes,which provides a reference for the future researches on bacterial resistance mechanism and new antibiotics and a new idea for the clinical control of tigecycline-resistant Acinetobacter baumannii.

Key words: Acinetobacter baumannii, Tigecycline, Drug resistance mechanism

CLC Number:

R378.99

ZHANG Xinyu, DU Xuefei, ZOU Guiling, JIANG Xiaofeng. Research progress of tigecycline resistance mechanism for Acinetobacter baumannii[J]. Laboratory Medicine, 2019, 34(7): 656-660.

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