Abstract: Objective To investigate the relationship between serum fetuin A level and insulin resistance（IR） in hyperthyroidism patients. Methods A total of 60 patients with hyperthyroidism treated with carbimazole were enrolled,and these patients were all cured. Totally,60 healthy subjects were enrolled as healthy control group. The general data of all subjects（age,sex,height,weight and so on） were collected. The levels of fetuin A,thyroid stimulating hormone（TSH）,free triiodothyronine（FT₃）,free thyroxine（FT₄）,insulin,C-reactive protein（CRP）,serum calcium and blood glucose were determined before and after treatment in hyperthyroidism group and healthy control group. Pearson correlation analysis was used to evaluate the correlation between fetuin A and various indicators. Results Body mass index（BMI） and TSH in hyperthyroidism group before treatment were lower than those after treatment and healthy control group（P<0.05）,and FT₃,FT₄,serum calcium,CRP,homeostasis model assessment for insulin resistance（HOMA-IR） and fetuin A were higher than those after treatment and healthy control group（P<0.05）. There was no statistical significance for BMI,TSH,FT₃,FT₄,serum calcium,CRP and fetuin A between hyperthyroidism after treatment and healthy control group（P>0.05）,but HOMA-IR was higher than that in healthy control group（P<0.05）. Before and after treatment,serum fetuin A was positively correlated with FT₃,FT₄,CRP and HOMA-IR（P<0.05）,and it was negatively correlated with TSH（P<0.05）,but there was no correlation with BMI and serum calcium（P>0.05）. Conclusions Elevated serum fetuin A level in hyperthyroidism patients may be related to IR.

Key words: Fetuin A, Hyperthyroidism, Insulin resistance, Carbimazole