Abstract:

Objective To investigate the changes of serum thyroid peroxidase antibody（TPOAb） and thyroglobulin antibody（TgAb） in patients with hyperthyroidism heart disease（HHD）. Methods A total of 100 patients with HHD and 100 patients with hyperthyroidism were enrolled,and their general data [sex,age,body mass index（BMI）,hyperthyroidism course and mean arterial pressure（MAP）] were collected. Serum TPOAb and TgAb levels were determined. Results There was no statistical significance for sex,age,BMI,hyperthyroidism course and MAP between HHD and hyperthyroidism groups （P>0.05）. Serum TPOAb and TgAb levels in HHD group were higher than those in hyperthyroidism group before and after treatment（P<0.001）. In HHD group,serum TPOAb and TgAb after treatment were lower than those before treatment（P<0.001）. There were 76 effective cases （76.00%） and 24 invalid cases（24.00%）in HHD group. After treatment,serum TPOAb and TgAb levels in effective cases were lower than those before treatment and in invalid cases（P<0.001）. For invalid cases,serum TPOAb and TgAb levels had no statistical significance before and after treatment （P>0.05）. Serum TPOAb and TgAb levels in effective cases after treatment had no statistical significance compared with hyperthyroidism group （P>0.05）. Conclusions Serum TPOAb and TgAb levels may be related to the occurrence and transfer of HHD,and they can be used as reference indices for evaluating curative effects.

Key words: Thyroid peroxidase antibody, Thyroglobulin antibody, Hyperthyroidism heart disease