Soluble endothelial protein C receptor and soluble thrombomodulin in patients with type 2 diabetes mellitus

doi:10.3969/j.issn.1673-8640.2017.03.012

Abstract

Abstract:

Objective To investigate the role of vascular endothelial injury in the development of microvascular complications in type 2 diabetes mellitus（DM）patients. Methods Enzyme-linked immunosorbent assay （ELISA） was used to determine for soluble endothelial protein C receptor（sEPCR） and soluble thrombomodulin（sTM） levels in 150 type 2 DM patients and 150 healthy subjects（healthy control group）. Results Compared with healthy control group,the levels of sEPCR and sTM in DM patients increased（P<0.05）. Conclusions The levels of sEPCR and sTM have correlations with the occurrence and severity of vessel diseases in DM patients,which can be biomarkers for evaluating endothelial function.

Key words: Soluble endothelial protein C receptor, Soluble thrombomodulin, Type 2 diabetes mellitus

CLC Number:

R446.1

QIAN Dingliang, YAN Shaorong, LIU Lingyun. Soluble endothelial protein C receptor and soluble thrombomodulin in patients with type 2 diabetes mellitus[J]. Laboratory Medicine, 2017, 32(3): 208-209.

组别	例数	sEPCR	sTM
DM组	150	147.32±51.25^*	29.95 ±8.91^*
正常对照组	150	116.92±19.93	18.99 ±2.89

组别	例数	sEPCR	sTM
DM组	150	147.32±51.25^*	29.95 ±8.91^*
正常对照组	150	116.92±19.93	18.99 ±2.89

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Soluble endothelial protein C receptor and soluble thrombomodulin in patients with type 2 diabetes mellitus

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