Abstract:

Objective To investigate the correlations of 25-hydroxyvitamin D level [25（OH）D] with folic acid（FA） and homocysteine（Hcy） in patients with type 2 diabetes mellitus（T2DM）. Methods Plasma levels of Hcy,FA and 25（OH） D were determined in 124 T2DM patients（T2DM group） and 40 healthy subjects（healthy control group）. According to 25（OH）D levels,T2DM group was classified into 4 groups,Q1 group [25（OH）D<10 ng/mL,20 cases],Q2 group [25（OH）D 10-<20 ng/mL,59 cases],Q3 group [25（OH）D 20-<30 ng/mL,31 cases] and Q4 group [25（OH）D≥30 ng/mL,14 cases]. Pearson linear correlation analysis was used to analyze the correlations of 25（OH）D with FA and Hcy. Results The levels of 25（OH）D and FA in T2DM group were lower than those in healthy control group（P<0.05）,and the level of Hcy was higher than that in healthy control group（P<0.05）. Among Q1,Q2,Q3 and Q4 groups,FA and Hcy levels had statistical significance（P<0.05）. The levels of 25（OH）D and Hcy had negative correlation（r=-0.213,P<0.05）,and the levels of 25（OH）D and FA were positively correlated（r=0.325,P<0.05）. Conclusions The deficiency of 25（OH）D and FA and the increasing of Hcy exist in patients with T2DM,and 25（OH）D was correlated with Hcy and FA.

Key words: 25-Hydroxyvitamin D, Folic acid, Homocysteine, Type 2 diabetes mellitus