Relationships of homocysteine,blood lipids and D-dimer with folic acid intervention in patients with acute cerebral stroke

doi:10.3969/j.issn.1673-8640.2016.011.003

Abstract

Abstract:

Objective To investigate the relationships of homocysteine（Hcy）,4 items of blood lipids [total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol（LDL-C） and high-density lipoprotein cholesterol（HDL-C）] and D-dimer（DD） with folic acid intervention in patients with acute cerebral stroke. Methods A total of 93 patients with acute cerebral stroke were enrolled. According to random number table,they were classified randomly into observation group（47 cases） and control group（46 cases）. Control group was treated with conventional therapy,and observation group was treated with conventional therapy combined with folic acid treatment. The 2 therapies lasted 4 weeks. The levels of Hcy,4 items of blood lipids and DD of the 2 groups were compared. Results Before therapies,plasma Hcy,TC,TG,LDL-C,HDL-C and DD levels showed no statistical significance between the 2 groups（P>0.05）. Plasma Hcy,TC,TG,LDL-C and DD levels in observation group were lower than those in control group after therapies（P<0.05）,and HDL-C level was higher than that in control group（P<0.05）. Conclusions Folic acid can reduce DD and Hcy levels in patients with acute cerebral stroke,which can improve patients' status of dyslipidemia.

Key words: Homocysteine, D-dimer, Blood lipids, Folic acid, Cerebral stroke

CLC Number:

R446.1

CANG Shenyuan. Relationships of homocysteine,blood lipids and D-dimer with folic acid intervention in patients with acute cerebral stroke[J]. Laboratory Medicine, 2016, 31(11): 941-943.

Figures/Tables 2

References 13

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组别	例数	Hcy（μmol/L）	TC（mmol/L）	TG（mmol/L）	LDL-C（mmol/L）	HDL-C（mmol/L）	DD（μg/L）
观察组	47	23.19±4.34	6.98±0.54	2.13±0.34	3.09±0.40	1.03±0.16	889.42±295.13
对照组	46	22.78±4.15	7.07±0.51	2.07±0.35	3.05±0.37	1.01±0.17	893.29±278.65
t值		0.465 5	1.144 2	0.838 6	0.500 3	0.771 3	0.065 0
P值		>0.05	>0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	Hcy（μmol/L）	TC（mmol/L）	TG（mmol/L）	LDL-C（mmol/L）	HDL-C（mmol/L）	DD（μg/L）
观察组	47	23.19±4.34	6.98±0.54	2.13±0.34	3.09±0.40	1.03±0.16	889.42±295.13
对照组	46	22.78±4.15	7.07±0.51	2.07±0.35	3.05±0.37	1.01±0.17	893.29±278.65
t值		0.465 5	1.144 2	0.838 6	0.500 3	0.771 3	0.065 0
P值		>0.05	>0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	Hcy（μmol/L）	TC（mmol/L）	TG（mmol/L）	LDL-C（mmol/L）	HDL-C（mmol/L）	DD（μg/L）
观察组	47	15.51±1.43	3.58±0.34	1.47±0.20	1.64±0.28	1.58±0.24	374.32±48.45
对照组	46	18.38±2.31	5.19±0.42	1.72±0.23	2.35±0.41	1.29±0.21	462.45±51.42
t值		7.220 9	20.339 2	5.597 1	9.770 6	6.196 2	8.508 5
P值		<0.05	<0.05	<0.05	<0.05	<0.05	<0.05

组别	例数	Hcy（μmol/L）	TC（mmol/L）	TG（mmol/L）	LDL-C（mmol/L）	HDL-C（mmol/L）	DD（μg/L）
观察组	47	15.51±1.43	3.58±0.34	1.47±0.20	1.64±0.28	1.58±0.24	374.32±48.45
对照组	46	18.38±2.31	5.19±0.42	1.72±0.23	2.35±0.41	1.29±0.21	462.45±51.42
t值		7.220 9	20.339 2	5.597 1	9.770 6	6.196 2	8.508 5
P值		<0.05	<0.05	<0.05	<0.05	<0.05	<0.05

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