The functions of c-jun, c-fos and BCL-2A genes and the influence of lead on them

doi:10.3969/j.issn.1673-8640.2014.02.020

Abstract

Abstract: Immediate-early genes (IEG) are one of the proto-oncogene families which can be induced by second messenger genes, belonging to the rapidly induced genes when treated with static cell mitogen. Such as c-fos and c-jun, which can be activated by second messenger, can produce the coupling effect of the short-term effects of extracellular signals and the long-term changes of cell function. These genes are firstly expressed after external stimuli, are the mediator linking cell biochemical changes to cell eventually specifically reacting to stimuli. IEGs encode the specific DNA binding proteins, affect the rate of transcription of target genes, involve in the intracellular signal transmission, and convert transient signals into long-time course reaction. Therefore, IEGs are considered as the third messengers. Currently, IEGs mainly include c-fos and c-jun family, c-myc and egr families. The expression of IEGs is related to the synaptic activity, and plays an important role in formation of long-term memory and consolidation of neural mechanisms. Studies have demonstrated that the expression of many IEGs has a very important role in consolidation of memory and neural plasticity mechanisms.

Key words: Immediate-early gene, Expression, Lead, Learning memory

CLC Number:

Q503

LIU Kangsheng, CAO Xiaoli, ZHONG Tianying, LI Xiling, GU Pingqing.. The functions of c-jun, c-fos and BCL-2A genes and the influence of lead on them[J]. , 2014, 29(2): 174-177.

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