Abstract:

Objective To investigate the change of P53 expression in paraffin biopsy specimens of breast cancer patients and its role in monitoring recurrence,metastasis and prognosis of breast cancer patients. Methods Immunohistochemical SP staining and in situ hybridization were used to determine the expression of P53 in paraffin biopsy specimens of 88 patients with breast cancer. The relationship between the expression of P53 and the prognosis of patients with breast cancer was analyzed according to clinical metastasis and recurrence. Results Immunohistochemical SP staining showed that P53 was overexpressed in 27 cases and underexpressed in 43 cases. In situ hybridization showed that P53 was overexpressed in 28 cases and underexpressed in 42 cases. The consistency rate of high P53 expression between the 2 methods was 100%. The sensitivity to chemotherapy and 5-year survival rate of patients with high P53 expression were lower than those of patients with low P53 expression（P<0.05）,while the recurrence and metastasis rates of patients with high P53 expression were higher than those of patients with low P53 expression（P<0.05）. Conclusions P53 may be an independent indicator for evaluating the recurrence,metastasis and 5-year survival of breast cancer patients.

Key words: P53, High expression, Recurrence and metastasis, Prognosis, 5-Year survival rate, Breast cancer