Abstract: Objective　To investigate the clinical significance of bone metabolism markers in patients with osteoporosis.   Methods　Bone mineral densities（BMD） of vertebral column and femur were measured by double functional X-ray digital bone density meter. A total of 74 patients were classified into 3 groups according to BMD：normal control（19 cases），bone-mass-reduction（25 cases） and osteoporosis（30 cases）. Serum parathyroid hormone（PTH），beta-Crosslaps（β-CTX），osteocalcin（N-MID） and 25-OH Vitamin D3 levels were detected by electrochemiluminescence immunoassay. Results　β-CTX and N-MID levels of osteoporosis group were significantly higher than those of normal control group and bone-mass-reduction group，and the difference had statistical significance（P＜0.05）. PTH and 25-OH Vitamin D3 levels had no statistical significance among the 3 groups（P＞0.05）. Conclusions　There is a close relationship between bone metabolism markers and osteoporosis. Serum bone turnover markers of β-CTX and N-MID are good indicators in the diagnosis of osteoporosis and fracture risk prediction.

Key words: Bone mineral density, Bone-mass-reduction, Osteoporosis, Parathyroid hormone, Beta-Crosslaps, Osteocalcin, 25-OH Vitamin D3