Abstract: Objective　To investigate the correlationship of transcription factor 7-like 2（TCF7L2） gene rs7903146 polymorphism and Chinese Han population in Suizhou district with type 2 diabetes mellitus. Methods　A total of 458 patients with type 2 diabetes mellitus（232 males and 226 females） had been diagnosed，and 186 healthy subjects（91 males and 95 females） with fasting blood glucose ＜5.6 mmol/L and without other systemic diseases were enrolled. The clinical indicators and glucose metabolism and lipid metabolism related indicators were measured. The polymerase chain reaction（PCR） TaqManTM fluorescence probe technique was used for allelic typing. The TCF7L2 gene rs7903146 polymorphism was analyzed. Results　TCF7L2 gene rs7903146 polymorphism was consistent with Hardy-Weinberg equilibrium law，and the frequencies of TCF7L2 gene rs7903146 C/C，C/T and T/T genotypes in type 2 diabetes mellitus group were 92.2%，7.6% and 0.2%，and the frequencies in the control group were 92.5%，7.5% and 0. No statistical difference between the 2 groups was found by χ² test. T allele frequencies in the type 2 diabetes mellitus group and control group were 4.0% and 3.8%，without statistical significance. Conclusions　TCF7L2 gene rs7903146 polymorphism is not the main pathogenic gene among Chinese Han population in Suizhou district with type 2 diabetes mellitus.

Key words: Transcription factor 7-like 2, Type 2 diabetes mellitus, Polymorphism