Abstract:

Objective To investigate the microbial distribution and drug resistance in chronic dacryocystitis，and to provide a reference for empirical clinical use. Methods A total of 104 patients with chronic dacryocystitis were enrolled from Xi'an First Hospital from June 2022 to June 2023，and the specimens of dacryocystic secretions were collected for identification by automated identification drug sensitivity instrument. In vitro drug susceptibility test was carried out by instrument method and disk diffusion method，and the consistency of the 2 methods was analyzed. Results The bacterial positive determination rate in patients with chronic dacryocystitis was 74.04%（77/104），with a total of 109 strains isolated，among them，75 cases of Gram-positive（68.81%），23 cases of Gram-negative（21.10%），10 cases of anaerobic bacteria（9.17%）and 1 case of fungus（0.92%）. The most sensitive antimicrobial drugs against Staphylococcus were moxifloxacin，rifampicin and vancomycin，with sensitivity rates of 80.00%，97.50% and 100.00%，respectively. The drug resistance rate of methicillin-resistant Staphylococcus（MRS）was higher than that of methicillin-sensitive Staphylococcus（MSS），and there was statistical significance for levofloxacin and clindamycin（P<0.05）. The consistency of drug susceptibility test between instrument method and disk diffusion method was good（Kappa value was 0.832，P<0.05）. Conclusions Staphylococcus is the main pathogen of chronic dacryocystitis，and moxifloxacin，rifampicin and vancomycin can be the drugs of choice for the treatment of chronic dacryocystitis.

Key words: Chronic dacryocystitis, Staphylococcus, Methicillin-resistant Staphylococcus, Drug resistance