Function and clinical role of serum orosomucoid

doi:10.3969/j.issn.1673-8640.2018.10.017

Abstract

Abstract:

Orosomucoid（ORM） is an acute phase reactive protein synthesized by many tissues and cells,but the liver is the main organ that synthesizes ORM. ORM can adjust various cells participating in innate and acquired immunity,balance energy metabolism,and fight fatigue. The levels of ORM in cells and blood have been shown to increase dramatically resulting from various tissue injuries. In the process of infection or trauma, blood ORM levels are continuously elevated in the multiple phases of inflammation. Therefore,monitoring the level of ORM in blood can be complemented with the current clinical index of emergency response C-reactive protein（CRP）. ORM can reflect the persistent,progress and fade status of inflammatory diseases and provide new clues to precise treatment. This review makes a comprehensive exposition of ORM from the aspects of structure,biological function and clinical significance of determining ORM.

Key words: Orosomucoid, C-reactive protein, Innate immunity, Acquired immunity

CLC Number:

R446.1

WANG Zhixue, HOU Xiaodan, JIN Xinyuan, SONG Mingming, LIU Xia, YANG Yili. Function and clinical role of serum orosomucoid[J]. Laboratory Medicine, 2018, 33(10): 943-948.

Figures/Tables 4

References 30

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