Abstract:

Objective To evaluate the real-time correction of whole blood C-reactive protein （CRP） determination using hematocrit （HCT） value in order to ensure the accuracy of determination results. Methods A total of 217 blood samples were collected. HCT<35% was found in 37 cases,HCT 35%-45% in 128 cases,and HCT>45% in 52 cases. The comparability of CRP levels before and after correcting in XN 2800 was evaluated. Results The mean deviation between uncorrected level and target CRP level by BN Ⅱ specific protein analyzer was 11.77 mg/L in 37 cases with HCT<35%,and the deviation was negatively correlated with the decrease of HCT,while the mean deviation between corrected and target CRP levels was 2.75 mg/L. In 128 cases with HCT 35%-45%,the mean deviation between uncorrected and target CRP levels was 2.79 mg/L,while the mean deviation between corrected and target CRP levels was 2.77 mg/L. In 52 cases with HCT>45%,the mean deviation between uncorrected and target CRP levels was -11.84 mg/L,and the deviation was positively correlated with the increase of HCT,while the mean deviation between corrected and target CRP levels was -1.35 mg/L. Conclusions As to blood samples with HCT<35% and HCT>45%,real-time correction of whole CRP value determination using HCT value can make the determination results more accurate.

Key words: Blood routine test, Hematocrit, C-reactive protein