Abstract:

Objective To study serum carbohydrate deficient transferrin（CDT）level of males with different nationalities in Xinjiang,and to assess the role of CDT in identifying alcohol abuse among males. Methods A questionnaire survey was conducted,and 131 healthy subjects （healthy control group,including 53 cases of Han,46 cases of Uygur and 32 cases of Kazak） and 96 subjects with alcohol abuse （alcohol abuse group,including 45 cases of Han,31 cases of Uygur and 20 cases of Kazak）were enrolled. Serum CDT level was determined by capillary electrophoresis. The reference interval and cut-off value were determined by P-P normality test and receiver operating characteristic（ROC） curve,respectively. Results The CDT level of alcohol abuse group was 3.530%±0.833%,which was higher than that of healthy control group （0.716%±0.341%,P<0.001）. There was no statistical significance for different nationalities in 2 groups（P>0.05）. The reference interval for serum CDT level in healthy control group was <1.28%. According to ROC curve,the cut-off value for alcohol abuse group was 1.25%,the sensitivity was 81.3%,and the specificity was 92.3%. The area under ROC curve was 0.948. Conclusions The reference interval of serum CDT level in healthy subjects with different nationalities in Xinjiang could use the same level. The determination of CDT has good sensitivity and specificity for identifying alcohol abuse,which meets clinical needs.

Key words: Carbohydrate deficient transferrin, Alcohol abuse, Reference interval, Nationalities