The protective effect of neutrophil gelatinase-associated lipocalin in acute kidney injury

doi:10.3969/j.issn.1673-8640.2015.01.020

Abstract

Abstract:

Acute kidney injury(AKI) is common in clinical practice, and the prognosis is so poor that needing early intervention, but now clinical diagnosis often depends on the functional indicators, such as serum creatinine (SCr) determination, however, due to the detection technology limitations, abnormal SCr appears much late, and the results may have some deviations, which is unfavorable about timely diagnosis and intervention of AKI, so it is urgent for a clear biomarker of early kidney damage. In recent years, scholars have been looking for the early biological markers of AKI, gradually finding some potentially useful indicators, such as neutrophil gelatinase-associated lipocalin(NGAL), kidney injury molecule-1(KIM-1), interleukin 18(IL-18), cystatin C(Cys C), N-acetyl-beta-D-glucosaminidase(NAG), liver fatty acid binding protein(L-FABP) and so on. NGAL as an early biomarker of AKI attracts much attention. Some studies show that NGAL also play an important role in protecting kidney inflammation and tumorigenesis, but the specific mechanism has not been fully understood yet. This review will discuss the protective role of NGAL in the occurrence of AKI and the related mechanisms.

Key words: Neutrophil gelatinase-associated lipocalin, Acute kidney injury, Apoptosis, Autophage

CLC Number:

R446.1

ZHANG Yali, CUI Liyan, ZHANG Jie.. The protective effect of neutrophil gelatinase-associated lipocalin in acute kidney injury[J]. Laboratory Medicine, 2015, 30(1): 80-84.

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